Results 1 to 10 of about 22,216 (225)

The Histone-Lysine N-Methyltransferase (KMT2) Family in Health and Disease. [PDF]

MedComm (2020)
This graphical abstract clarifies KMT2 family dysregulation and disease associations: its member mutations cause epigenetic imbalance and abnormal cell development; Menin/WDR5 inhibitors and other targeted therapies block aberrant epigenetic transcriptional programs, and combined synergistic therapies boost therapeutic efficacy.
Wang Q, Bo Z, Zhang Y, Chen Y, Wang Z, Tong S, Xu A, Zhang J, Liu Y.   +8 more
europepmc   +2 more sources

LSD1 deletion decreases exosomal PD-L1 and restores T-cell response in gastric cancer

Molecular Cancer, 2022
Background Histone lysine-specific demethylase 1 (LSD1) expression has been shown to be significantly elevated in gastric cancer (GC) and may be associated with the proliferation and metastasis of GC.
Lijuan Zhao, Ning Wang, Liuya Wei
exaly   +2 more sources

ZebraShare: a new venue for rapid dissemination of zebrafish mutant data [PDF]

PeerJ, 2021
Background In the past decade, the zebrafish community has widely embraced targeted mutagenesis technologies, resulting in an abundance of mutant lines.
April DeLaurier, Douglas G. Howe, Leyla Ruzicka, Adam N. Carte, Lacie Mishoe Hernandez, Kali J Wiggins, Mika M. Gallati, Kayce Vanpelt, Frances Loyo Rosado, Katlin G. Pugh, Chasey J. Shabdue, Khadijah Jihad, Summer B. Thyme, Jared C. Talbot   +13 more
doaj   +2 more sources

OTUD7B Deubiquitinates LSD1 to Govern Its Binding Partner Specificity, Homeostasis, and Breast Cancer Metastasis

Advanced Science, 2021
Genomic amplification of OTUD7B is frequently found across human cancers. But its role in tumorigenesis is poorly understood. Lysine‐specific demethylase 1 (LSD1) is known to execute epigenetic regulation by forming corepressor complex with CoREST ...
Zhicheng Gong, Aicun Li, Jiancheng Ding, Qing Li, Lei Zhang, Yuanpei Li, Zhe Meng, Fei Chen, Jialiang Huang, Dawang Zhou, Ronggui Hu, Jing Ye, Wen Liu, Han You   +13 more
doaj   +1 more source

Comparison of pharmacological inhibitors of lysine-specific demethylase 1 in glioblastoma stem cells reveals inhibitor-specific efficacy profiles

Frontiers in Neurology, 2023
IntroductionImproved therapies for glioblastoma (GBM) are desperately needed and require preclinical evaluation in models that capture tumor heterogeneity and intrinsic resistance seen in patients.
Lea M. Stitzlein, Lea M. Stitzlein, Achintyan Gangadharan, Leslie M. Walsh, Deokhwa Nam, Alexsandra B. Espejo, Melissa M. Singh, Kareena H. Patel, Yue Lu, Xiaoping Su, Ravesanker Ezhilarasan, Joy Gumin, Sanjay Singh, Erik Sulman, Frederick F. Lang, Joya Chandra, Joya Chandra, Joya Chandra   +17 more
doaj   +1 more source

Integrative analysis reveals histone demethylase LSD1 promotes RNA polymerase II pausing

iScience, 2022
Summary: Lysine-specific demethylase 1 (LSD1) is well-known for its role in decommissioning enhancers during mouse embryonic stem cell (ESC) differentiation.
Hani Jieun Kim, Pishun Li, Taiyun Kim, Andrew J. Oldfield, Xiaofeng Zheng, Pengyi Yang   +5 more
doaj   +1 more source

Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer. [PDF]

PLoS ONE, 2012
BACKGROUND: Lysine specific demethylase 1 (LSD1) has been identified and biochemically characterized in epigenetics, but the pathological roles of its dysfunction in lung cancer remain to be elucidated.
Tangfeng Lv, Dongmei Yuan, Xiaohui Miao, Yanling Lv, Ping Zhan, Xiaokun Shen, Yong Song   +6 more
doaj   +1 more source

LSD1 Promotes Prostate Cancer Cell Survival by Destabilizing FBXW7 at Post-Translational Level

Frontiers in Oncology, 2021
Prostate cancer (PCa) is the most common cancer in men and the fifth leading cause of cancer death worldwide. Unfortunately, castration-resistant prostate cancer (CRPCa) is incurable with surgical treat and prone to drug resistance.
Xu-ke Qin, Yang Du, Xiu-heng Liu, Lei Wang   +3 more
doaj   +1 more source

Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition

Nature Communications, 2023
The major enhancer regulator lysine-specific histone demethylase 1A (LSD1) is required for mammalian embryogenesis and is implicated in human congenital diseases and multiple types of cancer; however, the underlying mechanisms remain enigmatic.
Cheng Zeng, Jiwei Chen, Emmalee W. Cooke, Arijita Subuddhi, Eliana T. Roodman, Fei Xavier Chen, Kaixiang Cao   +6 more
doaj   +1 more source

LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function

JCI Insight, 2023
Lysine-specific demethylase 1 (LSD1) is a histone demethylase that promotes stemness and cell survival in cancers such as prostate cancer. Most prostate malignancies are adenocarcinomas with luminal differentiation.
Anbarasu Kumaraswamy, Zhi Duan, Diana Flores, Chao Zhang, Archana Sehrawat, Ya-Mei Hu, Olivia A. Swaim, Eva Rodansky, William K. Storck, Joshua A. Kuleape, Karan Bedi, Rahul Mannan, Xiao-Ming Wang, Aaron Udager, Visweswaran Ravikumar, Armand Bankhead III, Ilsa Coleman, John K. Lee, Colm Morrissey, Peter S. Nelson, Arul M. Chinnaiyan, Arvind Rao, Zheng Xia, Joel A. Yates, Joshi J. Alumkal   +24 more
doaj   +1 more source