Results 21 to 30 of about 12,312 (182)

Alternative splicing of LSD1+8a in neuroendocrine prostate cancer is mediated by SRRM4

Neoplasia: An International Journal for Oncology Research, 2020
Neuroendocrine prostate cancer (NEPC) is the most virulent form of prostate cancer. Importantly, our recent work examining metastatic biopsy samples demonstrates NEPC is increasing in frequency.
Daniel J. Coleman, David A. Sampson, Archana Sehrawat, Anbarasu Kumaraswamy, Duanchen Sun, Yuzhuo Wang, Jacob Schwartzman, Joshua Urrutia, Ahn R. Lee, Ilsa M. Coleman, Peter S. Nelson, Xuesen Dong, Colm Morrissey, Eva Corey, Zheng Xia, Joel A. Yates, Joshi J. Alumkal   +16 more
doaj   +1 more source

LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function

JCI Insight, 2023
Lysine-specific demethylase 1 (LSD1) is a histone demethylase that promotes stemness and cell survival in cancers such as prostate cancer. Most prostate malignancies are adenocarcinomas with luminal differentiation.
Anbarasu Kumaraswamy, Zhi Duan, Diana Flores, Chao Zhang, Archana Sehrawat, Ya-Mei Hu, Olivia A. Swaim, Eva Rodansky, William K. Storck, Joshua A. Kuleape, Karan Bedi, Rahul Mannan, Xiao-Ming Wang, Aaron Udager, Visweswaran Ravikumar, Armand Bankhead III, Ilsa Coleman, John K. Lee, Colm Morrissey, Peter S. Nelson, Arul M. Chinnaiyan, Arvind Rao, Zheng Xia, Joel A. Yates, Joshi J. Alumkal   +24 more
doaj   +1 more source

E3 ligase Trim35 inhibits LSD1 demethylase activity through K63-linked ubiquitination and enhances anti-tumor immunity in NSCLC

Cell Reports, 2023
Summary: Targeting lysine-specific histone demethylase 1A (LSD1) can improve tumor immunogenicity of poorly immunogenic tumors, such as non-small cell lung cancer (NSCLC), with elevated T cell infiltration and sensitize tumors to anti-PD-1 therapy ...
Feiyu Tang, Can Lu, Xiang He, Wei Lin, Bowen Xie, Xing Gao, Yang Peng, Desong Yang, Lunquan Sun, Liang Weng   +9 more
doaj   +1 more source

LSD1 and the chemistry of histone demethylation [PDF]

Current Opinion in Chemical Biology, 2007
The recent discovery that histone demethylation can be catalyzed by the flavin-dependent amine oxidase LSD1 has ushered in a new chapter in the chromatin-remodeling community. Herein, we discuss the rapid progress of the histone demethylase field including the recent identification of the non-heme iron-dependent histone demethylases (JmjC family), the ...
Jeffrey C, Culhane, Philip A, Cole
openaire   +2 more sources

Salicylic Acid Accumulation Controlled by LSD1 Is Essential in Triggering Cell Death in Response to Abiotic Stress

Cells, 2021
Salicylic acid (SA) is well known hormonal molecule involved in cell death regulation. In response to a broad range of environmental factors (e.g., high light, UV, pathogens attack), plants accumulate SA, which participates in cell death induction and ...
Maciej Jerzy Bernacki, Anna Rusaczonek, Weronika Czarnocka, Stanisław Karpiński   +3 more
doaj   +1 more source

Sanguinarine, identified as a natural alkaloid LSD1 inhibitor, suppresses lung cancer cell growth and migration [PDF]

Iranian Journal of Basic Medical Sciences, 2022
Objective(s): Lysine-specific demethylase1 (LSD1), an important class of histone demethylases, plays a crucial role in regulation of mammalian biology. The up-regulated LSD1 expression was frequently associated with progress and oncogenesis of multiple ...
Ting-ting Qin, Zhong-hua Li, Li-xin Li, Kun Du, Ji-ge Yang, Zhenqiang Zhang, Xiang-xiang Wu, Jinlian Ma   +7 more
doaj   +1 more source

Visualizing the Histone Code on LSD1 [PDF]

Cell, 2007
In this issue, Garcia-Bassets et al. (2007) show that spurious transcriptional activation by unliganded nuclear receptors is inhibited by histone lysine methylation. This inhibitory histone modification code is efficiently countered by the ligand-dependent recruitment of histone lysine demethylases, including lysine-specific demethylase 1 (LSD1), which
Gamble, Matthew J., Kraus, W. Lee
openaire   +2 more sources

Tertiary sulphonamide derivatives as dual acting small molecules that inhibit LSD1 and suppress tubulin polymerisation against liver cancer

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
A series of tertiary sulphonamide derivatives were synthesised and evaluated for their antiproliferative activity against liver cancer cell lines (SNU-475, HepG-2, and Bel-7402).
Lijuan Ding, Feng Wei, Nanya Wang, Yue Sun, Qiang Wang, Xia Fan, Ling Qi, Shudong Wang   +7 more
doaj   +1 more source

Trends of LSD1 Inhibitors in Viral Infections [PDF]

Future Medicinal Chemistry, 2018
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Zwergel, Clemens, Stazi, Giulia, Mai, Antonello, Valente, Sergio   +3 more
openaire   +3 more sources

The Deubiquitinase USP28 Stabilizes LSD1 and Confers Stem-Cell-like Traits to Breast Cancer Cells

Cell Reports, 2013
LSD1 is a critical chromatin modulator that controls cellular pluripotency and differentiation through the demethylation of H3K4me1/2. Overexpression of LSD1 has been observed in many types of tumors and is correlated with its oncogenic effects in ...
Yadi Wu, Yifan Wang, Xiuwei H. Yang, Tiebang Kang, Yongxiang Zhao, Chi Wang, B. Mark Evers, Binhua P. Zhou   +7 more
doaj   +1 more source