Results 41 to 50 of about 22,216 (225)
LSD1 inhibition attenuates androgen receptor V7 splice variant activation in castration resistant prostate cancer models [PDF]
, 2018 Background: Castrate resistant prostate cancer (CRPC) is often driven by constitutively active forms of the androgen receptor such as the V7 splice variant (AR-V7) and commonly becomes resistant to established hormonal therapy strategies such as ...
A. Ganesan +48 more
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Alteration of Epigenetic Regulation by Long Noncoding RNAs in Cancer [PDF]
, 2018 Long noncoding RNAs (lncRNAs) are important regulators of the epigenetic status of the human genome. Besides their participation to normal physiology, lncRNA expression and function have been already associated to many diseases, including cancer.
Fatica, Alessandro, Morlando, Mariangela
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Cell Reports, 2018 Summary: Pharmacologic inhibition of LSD1 promotes blast cell differentiation in acute myeloid leukemia (AML) with MLL translocations. The assumption has been that differentiation is induced through blockade of LSD1’s histone demethylase activity ...
Alba Maiques-Diaz +16 more
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Defective heart development in hypomorphic LSD1 mice [PDF]
Cell Research, 2011 Lysine-specific demethylase 1 (LSD1/AOF2/KDM1A), the first enzyme with specific lysine demethylase activity to be described, demethylates histone and non-histone proteins and is essential for mouse embryogenesis. LSD1 interacts with numerous proteins through several different domains, most notably the tower domain, an extended helical structure that ...
Thomas B, Nicholson +12 more
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Pharmacological inhibition of LSD1 activity blocks REST-dependent medulloblastoma cell migration
Cell Communication and Signaling, 2018 Background Medulloblastoma (MB) is the most common malignant brain tumor in children. Current problems in the clinic include metastasis, recurrence, and treatment-related sequelae that highlight the need for targeted therapies.
Keri Callegari +3 more
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Epigenetic regulation of LSD1 during mammary carcinogenesis [PDF]
Molecular & Cellular Oncology, 2014 Inheritable epigenetic regulation is integral to the dynamic control of gene expression under different stimuli for cellular homeostasis and disease progression. Histone methylation is a common and important type of chromatin modification. LSD1, the first known histone lysine-specific demethylase, operates as a key component of several corepressor ...
Wu, Yadi, Zhou, Binhua P
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Microenvironment and tumor cells: two targets for new molecular therapies of hepatocellular carcinoma. [PDF]
, 2018 Hepatocellular carcinoma (HCC), is one of the most frequent human cancer and is characterized by a high mortality rate. The aggressiveness appears strictly related to the liver pathological background on which cancer develops.
Amicone, Laura, Marchetti, Alessandra
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Diabetology & Metabolic Syndrome, 2022 Objective Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. Histone lysine-specific demethylase 1 (LSD1) is a flavin-containing amino oxidase that can repress or activate transcription.
Lina Dong, Lei Yu, Jin Zhong
doaj +1 more source
iScience, 2023 Summary: Lsd1/Kdm1a functions both as a histone demethylase enzyme and as a scaffold for assembling chromatin modifier and transcription factor complexes to regulate gene expression.
Mattie J. Casey +5 more
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Dual inhibitors of LSD1 and spermine oxidase [PDF]
MedChemComm, 2019 Dual inhibitors of LSD1 and SMOX, with no activity against N1-acetylpolyamine oxidase (PAOX).
Steven Holshouser +8 more
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