Results 31 to 40 of about 22,216 (225)

LSD1: Expanding Functions in Stem Cells and Differentiation [PDF]

Cells, 2021
Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful model system to uncover fundamental mechanisms that control cellular identity during mammalian development. Histone methylation governs gene expression programs that play a key role in the regulation of the balance between self-renewal and differentiation of ESCs ...
Carlos Martinez-Gamero, Sandhya Malla, Francesca Aguilo   +2 more
openaire   +4 more sources

The dual role of LESION SIMULATING DISEASE 1 as a condition-dependent scaffold protein and transcription regulator [PDF]

, 2017
Since its discovery over two decades ago as an important cell death regulator in Arabidopsis thaliana, the role of LESION SIMULATING DISEASE 1 (LSD1) has been studied intensively within both biotic and abiotic stress responses as well as with respect to ...
Balazadeh, Salma, Czarnocka, Weronika, Karpiński, Stanislaw, Mueller-Roeber, Bernd, Rusaczonek, Anna, Shahnejat-Bushehri, Sara, Szechynska-Hebda, Magdalena, Van Breusegem, Frank, Van Der Kelen, Katrien, Willems, Patrick   +9 more
core   +2 more sources

LSD1 Histone Demethylase Assays and Inhibition [PDF]

, 2016
The lysine-specific demethylase (LSD1) is a flavin-dependent amine oxidase that selectively removes one or two methyl groups from histone H3 at the Lys4 position. Along with histone deacetylases 1 and 2, LSD1 is involved in epigenetically silencing gene expression. LSD1 has been implicated as a potential therapeutic target in cancer and other diseases.
D, Hayward, P A, Cole
openaire   +2 more sources

Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation [PDF]

, 2014
Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic analysis, combining global occupancy
Fujiwara, Yuko, Guo, Guoji, Hsu, Yu-Jung, Kerenyi, Marc A, Luc, Sidinh, Nguyen, Minh, O'Brien, Kassandra, Orkin, Stuart H, Peng, Cong, Shao, Zhen   +9 more
core   +1 more source

SYNTHESIS, LSD1 INHIBITORY ACTIVITY, AND LSD1 BINDING MODEL OF OPTICALLY PURE LYSINE-PCPA CONJUGATES

Computational and Structural Biotechnology Journal, 2014
Compounds that inhibit the catalytic function of lysine-specific demethylase 1 (LSD1) are interesting as therapeutic agents. Recently, we identified three lysine-phenylcyclopropylamine conjugates, NCD18, NCD25, and NCD41, which are potent LSD1 inactivators.
Yukihiro Itoh, Daisuke Ogasawara, Yosuke Ota, Tamio Mizukami, Takayoshi Suzuki   +4 more
openaire   +3 more sources

Placental-mediated increased cytokine response to lipopolysaccharides: a potential mechanism for enhanced inflammation susceptibility of the preterm fetus. [PDF]

, 2012
BackgroundCerebral palsy is a nonprogressive motor impairment syndrome that has no effective cure. The etiology of most cases of cerebral palsy remains unknown; however, recent epidemiologic data have demonstrated an association between fetal neurologic ...
Belkacemi, Louiza, Beloosesky, Ron, Boles, Julie L, Desai, Mina, Ross, Michael G   +4 more
core   +1 more source

Tertiary sulphonamide derivatives as dual acting small molecules that inhibit LSD1 and suppress tubulin polymerisation against liver cancer

Journal of Enzyme Inhibition and Medicinal Chemistry, 2021
A series of tertiary sulphonamide derivatives were synthesised and evaluated for their antiproliferative activity against liver cancer cell lines (SNU-475, HepG-2, and Bel-7402).
Lijuan Ding, Feng Wei, Nanya Wang, Yue Sun, Qiang Wang, Xia Fan, Ling Qi, Shudong Wang   +7 more
doaj   +1 more source

Epigenetics in ovarian cancer: premise, properties, and perspectives. [PDF]

, 2018
Malignant ovarian tumors bear the highest mortality rate among all gynecological cancers. Both late tumor diagnosis and tolerance to available chemical therapy increase patient mortality.
Huang, Shuang, Lau, Bonnie, Lau, Wayne Bond, Tang, Kexin, Wang, Hongjing, Wang, Wei, Wang, Xin, Wei, Yuquan, Xu, Lian, Yang, Qilian, Yang, Yuqing, Yang, Zhengnan, Yi, Tao, Zhao, Linjie, Zhao, Xia, Zhou, Nianxin, Zhou, Shengtao   +16 more
core   +2 more sources

The Deubiquitinase USP28 Stabilizes LSD1 and Confers Stem-Cell-like Traits to Breast Cancer Cells

Cell Reports, 2013
LSD1 is a critical chromatin modulator that controls cellular pluripotency and differentiation through the demethylation of H3K4me1/2. Overexpression of LSD1 has been observed in many types of tumors and is correlated with its oncogenic effects in ...
Yadi Wu, Yifan Wang, Xiuwei H. Yang, Tiebang Kang, Yongxiang Zhao, Chi Wang, B. Mark Evers, Binhua P. Zhou   +7 more
doaj   +1 more source

The Epigenetic Controller Lysine-Specific Demethylase 1 (LSD1) Regulates the Outcome of Hepatitis C Viral Infection

Cells, 2023
Hepatitis C virus (HCV) alters gene expression epigenetically to rearrange the cellular microenvironment in a beneficial way for its life cycle. The host epigenetic changes induced by HCV lead to metabolic dysfunction and malignant transformation. Lysine-
Georgia Papadopoulou, Stavroula Petroulia, Eirini Karamichali, Alexios Dimitriadis, Dimitrios Marousis, Elisavet Ioannidou, Panagiota Papazafiri, John Koskinas, Pelagia Foka, Urania Georgopoulou   +9 more
doaj   +1 more source