Results 51 to 60 of about 22,216 (225)

Gene regulation and epigenotype in Friedreich's ataxia [PDF]

, 2008
Friedreich??????s ataxia (FRDA) is known to be provoked by an abnormal GAA-repeat expansion located in the first intron of the FXN gene. As a result of the GAA expansion, patients exhibit low levels of FXN mRNA, leading to FRDA.
Rothe, Nadine, Rothe, Nadine
core   +2 more sources

Expanding the Role of the Histone Lysine-Specific Demethylase LSD1 in Cancer [PDF]

, 2019
Studies of alterations in histone methylation in cancer have led to the identification of histone methyltransferases and demethylases as novel targets for therapy.
Amente, Stefano, Gorini, Francesca, Majello, Barbara, Saccà, Carmen Daniela   +3 more
core   +1 more source

The genetic equidistance result of molecular evolution is independent of mutation rates [PDF]

, 2008
The well-established genetic equidistance result shows that sister species are approximately equidistant to a simpler outgroup as measured by DNA or protein dissimilarity.
Shi Huang
core   +3 more sources

The PRMT5-LSD1 axis confers Slug dual transcriptional activities and promotes breast cancer progression

Journal of Experimental & Clinical Cancer Research, 2022
Background Downregulation of epithelial markers and upregulation of mesenchymal markers are the characteristics of the epithelial to mesenchymal transition (EMT) program, which provides the metastatic advantage of breast cancer.
Jianchao Zhang, Xiaokai Fan, Yunfan Zhou, Liang Chen, Hai Rao   +4 more
doaj   +1 more source

LSD1 and the chemistry of histone demethylation [PDF]

Current Opinion in Chemical Biology, 2007
The recent discovery that histone demethylation can be catalyzed by the flavin-dependent amine oxidase LSD1 has ushered in a new chapter in the chromatin-remodeling community. Herein, we discuss the rapid progress of the histone demethylase field including the recent identification of the non-heme iron-dependent histone demethylases (JmjC family), the ...
Jeffrey C, Culhane, Philip A, Cole
openaire   +2 more sources

Chromatin and oxygen sensing in the context of JmjC histone demethylases [PDF]

, 2014
Responding appropriately to changes in oxygen availability is essential for multicellular organism survival. Molecularly, cells have evolved intricate gene expression programmes to handle this stressful condition.
Abidi, Agger, Agger, Aik, Alena Shmakova, Allen, Banka, Barrett, Bersten, Beyer, Black, Clifton, Cloos, Copur, Couture, Cox, Curtis, Dalvai, De Santa, De Santa, Ehrbrecht, Elkins, Ene, Frescas, Frescas, Fukuda, Gearhart, Gildea, Grasso, Hayami, He, Hong, Inagaki, Ivan, Iwamori, Iwase, Jaakkola, Jensen, Jimena Druker, Johnson, Jones, Kauffman, Kenneth, Kleine-Kohlbrecher, Klose, Klose, Koivunen, Kooistra, Kottakis, Krieg, Krieser, Kruidenier, Lagarou, Lan, Lando, Laumonnier, Lee, Lee, Lee, Lee, Li, Liu, Lleres, Lorbeck, Lu, Maltby, Maxwell, Melvin, Melvin, Menon, Michael Batie, Mole, Moniz, Motoyama, Musselman, Narlikar, Niu, Oh, Okada, Okuno, Okuno, Osada, Owen-Hughes, Patani, Pfau, Pollard, Pryor, Ratcliffe, Rivera, Robinson, Robinson, Rocha, Rose, Rotili, Sanchez-Fernandez, Santos, Satoh, Sayegh, Schiller, Schnetz, Schodel, Scibetta, Scibetta, Semenza, Semenza, Shi, Shi, Sonia Rocha, Suzuki, Swygert, Tahiliani, Takeuchi, Tateishi, Tausendschön, Teng, Thinnes, Tie, Trewick, Tsukada, Tsukada, Tzatsos, Tzschach, Vinatzer, Wagner, Wang, Wang, Wang, Weber, Wellmann, Whetstine, Wissmann, Woon, Wozniak, Yamane, Yang, Yates, Yu, Zentner, Zhang, Zhou   +139 more
core   +5 more sources

Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia

Journal of Hematology & Oncology, 2016
Background Mixed lineage leukemia (MLL) gene translocations are found in ~75 % infant and 10 % adult acute leukemia, showing a poor prognosis. Lysine-specific demethylase 1 (LSD1) has recently been implicated to be a drug target for this subtype of ...
Zizhen Feng, Yuan Yao, Chao Zhou, Fengju Chen, Fangrui Wu, Liping Wei, Wei Liu, Shuo Dong, Michele Redell, Qianxing Mo, Yongcheng Song   +10 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

A Hypomorphic Lsd1 Allele Results in Heart Development Defects in Mice [PDF]

, 2013
Article Authors Metrics Comments Related Content Abstract Introduction Results Discussion Materials and Methods Supporting Information Acknowledgments Author Contributions References Reader Comments (0) Media Coverage (0) Figures Abstract Lysine-specific
Bajko, J, Capodieci, P, Chen, T, Cheng, X, Goetschkes, M, Hevi, S, Kinzel, B, Labow, M, Li, E, Li, M, Loureiro, J, Nicholson, TB, Singh, AK, Su, H, Valdez, R, Wang, J   +15 more
core   +3 more sources

Understanding and Overcoming Antibody‐Drug Conjugate Resistance: Biological Mechanisms and Emerging Analytical Frameworks in Breast Cancer

Advanced Science, EarlyView.
Antibody–drug conjugates (ADCs) transform breast cancer therapy, yet resistance limits their durability. Emerging evidence reveals that ADC failure is not solely tumor‐intrinsic but shaped by dynamic tumor–microenvironment interactions that alter drug delivery, processing, and response.
Minji Seo, Jangsoon Lee, Naoto T. Ueno
wiley   +1 more source