Results 11 to 20 of about 12,312 (182)
Strategies that regulate LSD1 for novel therapeutics
Acta Pharmaceutica Sinica BHistone methylation plays crucial roles in regulating chromatin structure and gene transcription in epigenetic modifications. Lysine-specific demethylase 1 (LSD1), the first identified histone demethylase, is universally overexpressed in various diseases.
Bin Yu
exaly +5 more sources
Acta Pharmaceutica Sinica B, 2019 Histone lysine-specific demethylase 1 (LSD1) has been implicated in the disease progression of several types of solid tumors. This study provides the first evidence showing that LSD1 overexpression occurred in 62.6% (224/358) of clear cell renal cell ...
Jianjun Sha, Jin Zhang, Mingyang Li
exaly +3 more sources
Frontiers in Neurology, 2023 IntroductionImproved therapies for glioblastoma (GBM) are desperately needed and require preclinical evaluation in models that capture tumor heterogeneity and intrinsic resistance seen in patients.
Lea M. Stitzlein +17 more
doaj +1 more source
Advanced Science, 2021 Genomic amplification of OTUD7B is frequently found across human cancers. But its role in tumorigenesis is poorly understood. Lysine‐specific demethylase 1 (LSD1) is known to execute epigenetic regulation by forming corepressor complex with CoREST ...
Zhicheng Gong +13 more
doaj +1 more source
Integrative analysis reveals histone demethylase LSD1 promotes RNA polymerase II pausing
iScience, 2022 Summary: Lysine-specific demethylase 1 (LSD1) is well-known for its role in decommissioning enhancers during mouse embryonic stem cell (ESC) differentiation.
Hani Jieun Kim +5 more
doaj +1 more source
LSD1 Promotes Prostate Cancer Cell Survival by Destabilizing FBXW7 at Post-Translational Level
Frontiers in Oncology, 2021 Prostate cancer (PCa) is the most common cancer in men and the fifth leading cause of cancer death worldwide. Unfortunately, castration-resistant prostate cancer (CRPCa) is incurable with surgical treat and prone to drug resistance.
Xu-ke Qin +3 more
doaj +1 more source
ZebraShare: a new venue for rapid dissemination of zebrafish mutant data [PDF]
PeerJ, 2021 Background In the past decade, the zebrafish community has widely embraced targeted mutagenesis technologies, resulting in an abundance of mutant lines.
April DeLaurier +13 more
doaj +2 more sources
Over-expression of LSD1 promotes proliferation, migration and invasion in non-small cell lung cancer. [PDF]
PLoS ONE, 2012 BACKGROUND: Lysine specific demethylase 1 (LSD1) has been identified and biochemically characterized in epigenetics, but the pathological roles of its dysfunction in lung cancer remain to be elucidated.
Tangfeng Lv +6 more
doaj +1 more source
LSD1: Biologic Roles and Therapeutic Targeting [PDF]
Epigenomics, 2016 LSD1 (KDM1A; BHC110; AOF2) was the first protein reported to exhibit histone demethylase activity and has since been shown to have multiple essential roles in mammalian biology. Given its enzymatic activity and its high-level expression in many human malignancies, a significant recent focus has been the development of pharmacologic inhibitors.
Maiques-Diaz, Alba, Somervaille, Tim Cp
openaire +4 more sources
Demethylase-independent roles of LSD1 in regulating enhancers and cell fate transition
Nature Communications, 2023 The major enhancer regulator lysine-specific histone demethylase 1A (LSD1) is required for mammalian embryogenesis and is implicated in human congenital diseases and multiple types of cancer; however, the underlying mechanisms remain enigmatic.
Cheng Zeng +6 more
doaj +1 more source