Results 41 to 50 of about 4,144 (256)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Pontoon trap for salmon and trout equipped with a seal exclusion device catches larger salmons.

open access: yesPLoS ONE, 2018
The growing seal populations of the Baltic have led to more frequent interactions with coastal fisheries. The motivation for seals to interact with fishing gear is high. It provides high densities of fish. A successful means of mitigating the conflict is
Linda Calamnius   +3 more
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Harvest selection on multiple traits in the wild revealed by aquatic animal telemetry

open access: yesEcology and Evolution, 2019
Harvesting can have profound impacts on the ecology and evolution of marine populations. However, little is known about the strength and direction of fisheries‐induced selection acting on multiple traits in the wild.
Even Moland   +4 more
doaj   +1 more source

The Present State of Traps and Fisheries Research in the Strait of Gibraltar [PDF]

open access: yes, 2019
The Strait of Gibraltar is defined as one of the most emblematic places in bluefin tuna biology, and the traps installed therein are platforms without equal in the study of this species. The enormous literature available on his fishing gear makes it impossible to make a full description from the historical point of view in the present study; however ...
José Luis Cort, Pablo Abaunza
openaire   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Sexual maturity of the deep-sea red crab Chaceon notialis Manning & Holthuis, 1989 (Brachyura: Geryonidae) in southern Brazil Madurez sexual del cangrejo rojo de profundidad Chaceon notialis Manning & Holthuis, 1989 (Brachyura: Geryonidae) al sur de Brasil

open access: yesLatin American Journal of Aquatic Research, 2009
The red crab Chaceon notialis is one of the three deep-sea crab species currently exploited in Brazil. The red crab fishery started in 1998 with foreign vessels that, as of 2000, have been extensively moni-tored by observers and tracked by satellite.
Rodrigo Sant'Ana, Paulo Ricardo Pezzuto
doaj  

Poverty in Golden Fishing: A Regulatory Impact Assessment of Fishermen Poverty in Indonesia

open access: yesPolicy & Governance Review, 2023
An area's wealth of natural resources can bring prosperity to its people. However, this is not the case with the fishermen in the Maluku Tengah Regency, Maluku, Indonesia, who live in the Golden Fishing area.
La Sugi
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

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