Results 91 to 100 of about 1,921,606 (253)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Monetary Policy and Japan’s Liquidity Trap [PDF]

open access: yes
During the long economic slump in Japan, monetary policy in Japan has essentially consisted of a very low interest rate (since 1995), a zero interest rate (since 1999), and quantitative easing (since 2001).
Lars E.O. Svensson
core  

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird   +9 more
wiley   +1 more source

Tomahawk Double Door Collapsible Fish Trap (Model 401) - side view

open access: yes, 2001
Repeating fish trap (12"" x 12"" x 36"") with 1 x 1 mesh openings (14 gauge) and two trap doors - collapses to one inch in ...
Tomahawk Live Trap Co.
core  

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit   +11 more
wiley   +1 more source

Tomahawk Economy Trap (Model 66)

open access: yes, 2001
Economy Cat/ Rabbit Transfer Trap (26 x 9 x 9) with 1 x 1 mesh openings (14 gauge) and a rear release door - for less frequent ...
Tomahawk Live Trap Co.
core  

Twin reversed arterial perfusion sequence in monochorionic twin pregnancy going undetected up to delivery: A case report

open access: yesJournal of Indira Gandhi Institute of Medical Sciences
Acardiac malformation is a well-known complication of monozygotic twins. Pathogenesis involves the pumping of blood from a donor twin to an acardiac twin through its umbilical arteries anastomosing at the level of the placenta through abnormal ...
Rajvir Kaur   +3 more
doaj   +1 more source

Boundary‐Dependent Sleep–Wake Dysregulation in Idiopathic Hypersomnia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Idiopathic hypersomnia (IH) presents with excessive daytime sleepiness (EDS) despite apparently preserved nocturnal sleep, challenging traditional models of hypersomnolence based on sleep loss or fragmentation. We aimed to test the hypothesis that EDS in IH reflects excessive stabilization of the sleep state, consistent with ...
Samantha Mombelli   +13 more
wiley   +1 more source

TRAP-CSP fusion protein purification.

open access: yes, 2020
(A-C) Pb fusion proteins. (A) Fusions purified by Ni-NTA affinity chromatography were treated with or without Endo H and subjected to reducing SDS-PAGE and Coomassie blue staining. Arrows point to N-glycosylated (glyco) and Endo H-treated (dNG) bands and
Gaojie Song (8345775)   +8 more
core   +1 more source

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