Results 71 to 80 of about 1,921,606 (253)

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

A phase 2b randomised trial of the candidate malaria vaccines FP9 ME-TRAP and MVA ME-TRAP among children in Kenya. [PDF]

, 2006
OBJECTIVE: The objective was to measure the efficacy of the vaccination regimen FFM ME-TRAP in preventing episodes of clinical malaria among children in a malaria endemic area.
Lowe, B, Bejon, P, Hill, Adrian, Gilbert, Sarah, Lang Trudie, Lang, T, Peshu, N, Lowe, Brett, Molyneux, C, Fegan Greg, Hill, AV, Milligan Paul, Hill Adrian V. S, Gilbert, Sarah C, Bejon, Philip, Marsh Kevin, Mwacharo Jedidah, Mwangi, T, Mwangi, Tabitha, Fegan, G, Todryk, S, Molyneux, Catherine, Keating, S, Kai, Oscar, Lang, Trudie, Gilbert, SC, Mwacharo, J, Gikonyo, C, Molyneux Catherine, Kai, O, Gilbert Sarah C, Keating, Sheila, Mwangi Tabitha, Todryk, Stephen, Hill, Adrian VS, Kai Oscar, Greg Fegan, Mwacharo, Jedidah, Peshu, Norbert, Todryk Stephen, Milligan, Paul, Marsh, K, Peshu Norbert, Lowe Brett, Gikonyo, Caroline, Bejon Philip, Fegan, Greg, Milligan, P, Keating Sheila, Marsh, Kevin, Gikonyo Caroline   +50 more
core   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

TRAP SEQUENCE: CASE REPORT

, 2006
TRAP sequence is a syndrome, seen in monochorionic twin pregnancies with poor prognosis and with a 1/100 incidence. It is characterized with a recipient fetus exhibiting lethal anomalies including acardia and a pump fetus supplying blood by vascular ...
TOPUZ, Samet, Kalelioglu, Brahim, HAS, Recep, Berkman, Sinan, Akhan, Sleyman Engin, Kartal, Altay, Iyibozkurt, Ahmet Cem   +6 more
core  

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Tomahawk Collapsible Trap (Model 201)

, 2001
A Single Door Chipmunk/ Rat Trap (16 x 5 x 5) with ??
Tomahawk Live Trap Co.
core  

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Tomahawk Economy Trap (Model 68)

, 2001
Economy Raccoon/ Feral Cat Transfer Trap (32 x 10 x 12) with 1 x 2 mesh openings (12 gauge) and a rear release door - for less frequent ...
Tomahawk Live Trap Co.
core