Results 41 to 50 of about 164,947 (266)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Large-Scale Deployment of Lehmann’s Funnel Entry Traps to Control Malaria Mosquito Populations

Tropical Medicine and Infectious Disease
Effective tools to prevent mosquito bites are essential for malaria control. The Lehmann Funnel Entry Trap (LFET), a window screen proven effective in reducing mosquito density, was tested for its large-scale impact on malaria vector control and ...
Hamidou Maïga, Roger Sanou, Bazoumana B. D. Sow, Adama Ouema, Abdoul Azize Millogo, Koama Bayili, Aristide Sawdetuo Hien, Simon P. Sawadogo, Souro Abel Millogo, Adrien Marie Gaston Belem, Léa Paré Toé, Roch K. Dabiré, Abdoulaye Diabaté   +12 more
doaj   +1 more source

Identifying Defects without a priori Knowledge in a Room-Temperature Semiconductor Detector Using Physics Inspired Machine Learning Model

Sensors, 2023
Room-temperature semiconductor radiation detectors (RTSD) such as CdZnTe are popular in Computed Tomography (CT) imaging and other applications. Transport properties and material defects with respect to electron and hole transport often need to be ...
Srutarshi Banerjee, Miesher Rodrigues, Manuel Ballester, Alexander Hans Vija, Aggelos Katsaggelos   +4 more
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Abnormal Temperature and Bias Dependence of Threshold Voltage Instability in p-GaN/AlGaN/GaN HEMTs

IEEE Journal of the Electron Devices Society
In this work, we investigated the instability of threshold voltage (Vth) in p-GaN/AlGaN/GaN high electron mobility transistors (HEMTs) under positive gate biases and high temperatures.
Myeongsu Chae, Ho-Young Cha, Hyungtak Kim   +2 more
doaj   +1 more source

Using Internet of Things (IoT), Near-Infrared Spectroscopy (NIRS), and Hyperspectral Imaging (HSI) to Enhance Monitoring and Detection of Grain Pests in Storage and Handling Operators

Agriculture, 2023
To reduce the use of insecticides, silo operators are reconsidering their practices and implementing integrated pest management (IPM) to manage insect infestations.
Katell Crépon, Marine Cabacos, Félix Bonduelle, Faten Ammari, Marlène Faure, Séverine Maudemain   +5 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Is unreliable science guiding bobcat management in Wyoming and other western U.S. states?

Ecological Solutions and Evidence, 2022
Wildlife managers require defensible and transparent population estimates to justify species management. Statistical population reconstruction (SPR) is being widely adopted to estimate wildlife population sizes from hunter harvest data.
Sean M. Murphy, Susan Eriksen‐Meier, Lisa Robertson, L. Mark Elbroch   +3 more
doaj   +1 more source

Preliminary data on attractiveness of phenylacetaldehyde-based lures on economically important plant bug pests (Hemiptera: Miridae)

International Journal of Horticultural Science, 2021
Several plant bug species (Miridae) are important pests of crops and vegetables, thus monitoring them is of essential importance for effective pest control.
T. Szalárdi, A. Nagy, F. Oláh, M. Tóth, S. Koczor   +4 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source