Results 51 to 60 of about 834,405 (345)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The Coffee Berry Borer (<em>Hypothenemus hampei</em>) Invades Hawaii: Preliminary Investigations on Trap Response and Alternate Hosts

Insects, 2012
In August 2010 the coffee berry borer, <em>Hypothenemus hampei</em>, was first reported to have invaded the Kona coffee growing region of Hawaii, posing a severe economic challenge to the fourth largest agricultural commodity in the State ...
Russell H. Messing
doaj   +1 more source

Dynamics of a chain of optically coupled micro droplets [PDF]

Journal of the European Optical Society-Rapid Publications, 2013
We study a chain of fluid droplets excited by two incoherent laser beams. Such structured object is merely an array of spherical lenses, that can guide a TEMpq optical mode.
Crouzil Th., Perrin M.
doaj   +1 more source

Rotational dynamics of optically trapped polymeric nanofibers

, 2009
The optical trapping of polymeric nanofibers and the characterization of the rotational dynamics are reported. A strategy to apply a torque to a polymer nanofiber, by tilting the trapped fibers using a symmetrical linear polarized Gaussian beam is ...
Andrea Camposeo, Antonio Alvaro Ranha Neves, Berg-Sørensen, Bishop, Bonin, Borghese, Borghese, Broersma, Camposeo, Dario Pisignano, Dholakia, Di Benedetto, Ferdinando Borghese, Friese, Galajda, Galajda, Gauthier, He, Higurashi, Higurashi, Higurashi, Jonáš, Leach, Li, Lock, Lock, Lock, Maragò, Maria Antonia Iatì, Moffitt, Moran-Mirabal, Nakayama, Neves, Neves, Onofrio M. Maragò, O’Neil, Padgett, Paolo Denti, Parkin, Paterson, Pauzauskie, Pinto, Polaert, Reneker, Richards, Roberto Cingolani, Rosalba Saija, Santamato, Sato, Simpson, Stefano Pagliara, Xu   +51 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Radiation trapping in coherent media [PDF]

, 2001
We show that the effective decay rate of Zeeman coherence, generated in a Rb87 vapor by linearly polarized laser light, increases significantly with the atomic density. We explain this phenomenon as the result of radiation trapping.
Matsko, A. B., Novikova, I., Scully, M. O., Welch, G. R.   +3 more
core   +4 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Large-Scale Deployment of Lehmann’s Funnel Entry Traps to Control Malaria Mosquito Populations

Tropical Medicine and Infectious Disease
Effective tools to prevent mosquito bites are essential for malaria control. The Lehmann Funnel Entry Trap (LFET), a window screen proven effective in reducing mosquito density, was tested for its large-scale impact on malaria vector control and ...
Hamidou Maïga, Roger Sanou, Bazoumana B. D. Sow, Adama Ouema, Abdoul Azize Millogo, Koama Bayili, Aristide Sawdetuo Hien, Simon P. Sawadogo, Souro Abel Millogo, Adrien Marie Gaston Belem, Léa Paré Toé, Roch K. Dabiré, Abdoulaye Diabaté   +12 more
doaj   +1 more source

Identifying Defects without a priori Knowledge in a Room-Temperature Semiconductor Detector Using Physics Inspired Machine Learning Model

Sensors, 2023
Room-temperature semiconductor radiation detectors (RTSD) such as CdZnTe are popular in Computed Tomography (CT) imaging and other applications. Transport properties and material defects with respect to electron and hole transport often need to be ...
Srutarshi Banerjee, Miesher Rodrigues, Manuel Ballester, Alexander Hans Vija, Aggelos Katsaggelos   +4 more
doaj   +1 more source

Laser frequency locking with 46 GHz offset using an electro-optic modulator for magneto-optical trapping of francium atoms

, 2016
We demonstrated a frequency offset locking between two laser sources using a waveguide-type electro-optic modulator (EOM) with 10th-order sidebands for magneto-optical trapping of Fr atoms.
Ando, S., Aoki, T., Aoki, T., Arikawa, H., Ezure, S., Harada, K., Hatakeyama, A., Hatanaka, K., Hayamizu, T., Imai, K., Inoue, T., Ishikawa, T., Ito, S., Itoh, M., Kato, K., Kawamura, H., Murakami, T., Nataraj, H. S., Sakamoto, K., Sakemi, Y., Sato, T., Shimizu, Y., Uchiyama, A., Wakasa, T., Yoshida, H. P.   +24 more
core   +1 more source