Results 71 to 80 of about 1,751,193 (294)

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Kidney and uro-trauma: WSES-AAST guidelines

World Journal of Emergency Surgery, 2019
Renal and urogenital injuries occur in approximately 10-20% of abdominal trauma in adults and children. Optimal management should take into consideration the anatomic injury, the hemodynamic status, and the associated injuries.
F. Coccolini, E. Moore, Y. Kluger, W. Biffl, A. Leppãniemi, Y. Matsumura, F. Kim, A. Peitzman, G. Fraga, M. Sartelli, L. Ansaloni, G. Augustin, A. Kirkpatrick, F. Abu-Zidan, I. Wani, D. Weber, E. Pikoulis, Martha Larrea, C. Arvieux, V. Manchev, V. Reva, R. Coimbra, V. Khokha, A. C. Mefire, C. Ordoñez, M. Chiarugi, Fernando Machado, B. Sakakushev, J. Matsumoto, R. Maier, I. Di Carlo, F. Catena, Paola Martijn Mohan Edward Matti Marco Carlos Augusto Ni Fugazzola Stommel Rajashekar Tan Tolonen Ceresoli , P. Fugazzola, Martijn Stommel, M. Rajashekar, E. Tan, M. Tolonen, M. Ceresoli, Carlos Augusto Gómez, Niccolò Allievi, M. Chirica, Francesco Salvetti, R. Bertelli, O. Ben-Ishay, H. Bahouth, G. Baiocchi, A. Tarasconi, Stefania Cimbanassi, O. Chiara, Richard ten-Broek, G. Montori, E. Picariello, L. Solaini, A. Hecker, M. Tomasoni, P. Perfetti, N. Parry, N. dèAngelis, B. Pereira, Joaquín Bado, O. Romeo, Andreas Pikoulis, M. Bala, L. Napolitano, Joseph M. Galante, S. Rizoli, Paula Ferrada, T. Horer, M. Brenner, R. Ivatury   +70 more
semanticscholar   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Blunt carotid injury with thrombotic occlusion: Is an intervention always required for best outcome?

Trauma Case Reports, 2019
Blunt cerebrovascular injuries are rare, comprises of 0.08 to 0.33% of all traumatic blunt injuries. Depending on the grade of severity, they may heal with minimal consequences or may lead to debilitating and devastating stroke.
Amulya Rattan, Ruby Kataria, Ajay Kumar, Quamar Azam, Md   +3 more
doaj   +1 more source

Pelvic trauma: WSES classification and guidelines

World Journal of Emergency Surgery, 2017
Complex pelvic injuries are among the most dangerous and deadly trauma related lesions. Different classification systems exist, some are based on the mechanism of injury, some on anatomic patterns and some are focusing on the resulting instability ...
F. Coccolini, P. Stahel, G. Montori, W. Biffl, T. Horer, F. Catena, Y. Kluger, E. Moore, A. Peitzman, R. Ivatury, R. Coimbra, G. Fraga, B. Pereira, S. Rizoli, A. Kirkpatrick, A. Leppãniemi, R. Manfredi, S. Magnone, O. Chiara, L. Solaini, M. Ceresoli, Niccolò Allievi, C. Arvieux, G. Velmahos, Z. Balogh, N. Naidoo, D. Weber, F. Abu-Zidan, M. Sartelli, L. Ansaloni   +29 more
semanticscholar   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Splenic trauma: WSES classification and guidelines for adult and pediatric patients

World Journal of Emergency Surgery, 2017
Spleen injuries are among the most frequent trauma-related injuries. At present, they are classified according to the anatomy of the injury. The optimal treatment strategy, however, should keep into consideration the hemodynamic status, the anatomic ...
F. Coccolini, G. Montori, F. Catena, Y. Kluger, W. Biffl, E. Moore, V. Reva, Camilla Bing, M. Bala, P. Fugazzola, H. Bahouth, I. Marzi, G. Velmahos, R. Ivatury, K. Søreide, T. Horer, R. T. ten Broek, B. Pereira, G. Fraga, K. Inaba, J. Kashuk, N. Parry, P. Masiakos, K. Mylonas, A. Kirkpatrick, F. Abu-Zidan, C. Gomes, S. V. Benatti, N. Naidoo, Francesco Salvetti, S. Maccatrozzo, V. Agnoletti, E. Gamberini, L. Solaini, A. Costanzo, A. Celotti, M. Tomasoni, V. Khokha, C. Arvieux, L. Napolitano, L. Handolin, M. Pisano, S. Magnone, D. Spain, M. D. de Moya, K. Davis, Nicola de’ Angelis, A. Leppãniemi, Paula Ferrada, R. Latifi, D. Navarro, Y. Otomo, R. Coimbra, R. Maier, F. Moore, S. Rizoli, B. Sakakushev, Joseph M. Galante, O. Chiara, Stefania Cimbanassi, A. C. Mefire, D. Weber, M. Ceresoli, A. Peitzman, Liban Wehlie, M. Sartelli, S. di Saverio, L. Ansaloni   +67 more
semanticscholar   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Chemokine analysis as a novel diagnostic modality in the early prediction of the outcome of non-union therapy: a matched pair analysis

Journal of Orthopaedic Surgery and Research, 2018
Background Despite the regenerative capability of skeletal tissue fracture, non-union is common. Treatment of non-unions remains challenging, and early determination of the outcome is impossible.
Patrick Haubruck, Anja Solte, Raban Heller, Volker Daniel, Michael Tanner, Arash Moghaddam, Gerhard Schmidmaier, Christian Fischer   +7 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source