Results 71 to 80 of about 2,995,823 (376)

Complex Limb Injuries: Limb Salvage Versus Amputation—A Mini Review and Meta-Analysis

open access: yesAdvances in Orthopedics
Conclusion: Managing complex limb injuries effectively necessitates a comprehensive approach involving thorough assessment, multidisciplinary collaboration, and patient-centered care.
Athanasios Serlis   +5 more
doaj   +1 more source

Respiratory Function Tolerance of Rats with Vaying Degrees of Thoracic Volume Reduction

open access: yesOrthopaedic Surgery, 2023
Objective To compare the effects of respiratory function on different degrees of reduced thoracic volume and evaluate the tolerance of rats with reduced thoracic volume, and to assess the feasibility of thoracic volume as a measure of the severity of rib
Jiuxu Deng   +6 more
doaj   +1 more source

Collective Trauma and the Social Construction of Meaning

open access: yesFrontiers in Psychology, 2018
Collective trauma is a cataclysmic event that shatters the basic fabric of society. Aside from the horrific loss of life, collective trauma is also a crisis of meaning. The current paper systematically delineates the process that begins with a collective
Gilad Hirschberger
semanticscholar   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu   +11 more
wiley   +1 more source

“Owl” Technique for All-Arthroscopic Augmentation of a Massive or Large Rotator Cuff Tear With Extracellular Matrix Graft

open access: yesArthroscopy Techniques, 2016
Despite the vast improvement in techniques and technology for arthroscopic rotator cuff surgery, repairs of massive and large tears remain challenging because they are associated with significantly high failure rates.
A. Ali Narvani, M.B.B.S.(Hons), M.Sc.(Sports Med)(Hons), F.R.C.S.(Orth&Trauma), M.F.S.E.M.(UK)   +5 more
doaj  

Epidemiology of traumatic falls after Hurricane Maria in Puerto Rico

open access: yesInjury Epidemiology, 2020
Background Hurricanes are among the most devastating natural disasters, playing a significant role in public health. Currently, the epidemiology of fall-related injuries after the occurrence of a tropical storm is not well described.
Laura Ramírez-Martínez   +6 more
doaj   +1 more source

A paradigm shift: relationships in trauma-informed mental health services

open access: yesBJ Psych Advances, 2018
SUMMARY Trauma-informed approaches emerged partly in response to research demonstrating that trauma is widespread across society, that it is highly correlated with mental health and that this is a costly public health issue.
A. Sweeney   +4 more
semanticscholar   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

open access: yesMolecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo   +11 more
wiley   +1 more source

Predictive factors for docking site procedure in bone transport for large lower extremity segmental defects

open access: yesBMC Musculoskeletal Disorders, 2023
Background Segmental bone transport is a common technique for treating large segmental bone defects. However, a docking site procedure is often necessary in segmental bone transport.
T. Omar Pacha   +8 more
doaj   +1 more source

Home - About - Disclaimer - Privacy