Results 81 to 90 of about 1,751,193 (294)

Clinical patterns and predictors of trauma-related mortality over 13 years: a retrospective analysis from a Level 1 National trauma center

World Journal of Emergency Surgery
Background Qatar is one of six neighboring countries in the Gulf Cooperation Council region that form a political and economic alliance to foster multilateral cooperation.
Ayman El-Menyar, Sandro Rizoli, Ahammed Mekkodathil, Mohammad Asim, Sajid Atique, Abdel-Aziz Hammo, Hisham Jogol, Ahad Kanbar, Khalid Ahmed, Rafael Consunji, Husham Abdelrahman, Asmaa Al-Atey, Ahmad Kloub, Fernando Spencer Netto, Gustav Strandvik, Hassan Al-Thani   +15 more
doaj   +1 more source

Percutaneous versus open posterior stabilization in AOSpine type A3 thoracolumbar fractures

BMC Musculoskeletal Disorders, 2020
Background The purpose of this retrospective cohort study was to compare treatment strategies of two level-one trauma centers regarding clinical and radiological outcomes focusing on non-osteoporotic AOSpine type A3 fractures of the thoracolumbar spine ...
Christoph J. Erichsen, Christoph-Eckhard Heyde, Christoph Josten, Oliver Gonschorek, Stephanie Panzer, Christian von Rüden, Ulrich J. Spiegl   +6 more
doaj   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

The impact of recreational marijuana commercialization on traumatic injury

Injury Epidemiology, 2019
Background The medical legalization of marijuana has been shown to result in an increased risk of motor vehicle injuries. In Colorado, commercialization of recreational marijuana (initiation of retail sales) occurred on January 1, 2014, resulting in the ...
Christine Chung, Kristin Salottolo, Allen Tanner, Matthew M. Carrick, Robert Madayag, Gina Berg, Mark Lieser, David Bar-Or   +7 more
doaj   +1 more source

The why and how our trauma patients die: A prospective Multicenter Western Trauma Association study

Journal of Trauma and Acute Care Surgery, 2019
BACKGROUND Historically, hemorrhage has been attributed as the leading cause (40%) of early death. However, a rigorous, real-time classification of the cause of death (COD) has not been performed.
R. Callcut, L. Kornblith, A. Conroy, Anamaria J Robles, J. Meizoso, N. Namias, D. Meyer, Amanda Haymaker, Michael S. Truitt, Vaidehi Agrawal, James M. Haan, Kelly L. Lightwine, J. Porter, Janika L. San Roman, W. Biffl, M. S. Hayashi, M. Sise, Jayraan Badiee, G. Recinos, K. Inaba, T. Schroeppel, Emma Callaghan, Julie A. Dunn, Samuel Godin, R. McIntyre, E. Peltz, P. O’Neill, C. Diven, Aaron M. Scifres, Emily E. Switzer, M. West, Sarah Storrs, D. Cullinane, J. Cordova, E. Moore, H. Moore, A. Privette, E. Eriksson, M. Cohen   +38 more
semanticscholar   +1 more source

Predicting Mortality of Korean Geriatric Trauma Patients: A Comparison between Geriatric Trauma Outcome Score and Trauma and Injury Severity Score

, 2021
Jiye Park, Yunhwan Lee
openalex   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Boosting tendon repair: interplay of cells, growth factors and scaffold-free and gel-based carriers

Journal of Experimental Orthopaedics, 2018
Background Tendons are dense connective tissues and critical components for the integrity and function of the musculoskeletal system. Tendons connect bone to muscle and transmit forces on which locomotion entirely depends.
Zexing Yan, Heyong Yin, Michael Nerlich, Christian G. Pfeifer, Denitsa Docheva   +4 more
doaj   +1 more source