Results 111 to 120 of about 344,176 (305)

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

The Performance of Trauma Research Centers of Iran during the Past 10 Years; A Science Monitor Survey [PDF]

Bulletin of Emergency and Trauma, 2014
Objective: To compare and evaluation of scores of trauma research center of Shiraz University of Medical Sciences in Iran with other trauma research centers in Iran. Methods: The assessment scores of each center were gathered from Iran medical research
Mahnaz Yadollahi, Narges Shamsedini, Leila Shayan, Abbas Rezaianzadeh, Shahram Bolandparvaz   +4 more
doaj   +1 more source

Filling the Void: A Low Cost, High-Yield Method to Addressing Incidental Findings in Trauma Patients [PDF]

, 2017
In this study we: Report the incidence of incidental findings in a suburban trauma center treating primarily blunt and elderly trauma Propose simple solutions to increase the rate of disclosure to patientshttps://jdc.jefferson.edu/patientsafetyposters ...
Alswealmeen, W., Bertozzi, D., Gartner, L., Kirton, O., Lim, P., Rogers, A., Sabapathi, P., Shadis, R., Sich, N., Sternlieb, J., Yuschak, J.   +10 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

User-Centered Design of Trauma Systems Solutions for Retriage of Patients With Injury: Mixed Methods Study

Journal of Medical Internet Research
BackgroundRetriage is the emergent interhospital transfer of severely injured patients from nontrauma and low-level trauma centers to high-level trauma centers.
John Dwight Slocum, David Jelke, Qixuan Mai, Julie K Johnson, My L T Nguyen, Lixuan Cong, Adithya Chandrasekaran, Jane L Holl, Yuriy Moklyak, Justin Mis, Molly Gabaldo, James G Adams, William M Brigode, Mary Beth Voights, Rebecca Andersen, Tamuriat Gilbert, Nicole Siparsky, Arthur Proust, Anne M Stey, Andrew B L Berry   +19 more
doaj   +1 more source

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Trauma Exposure Among Women in the Pacific Rim [PDF]

, 2017
Purpose Healthcare professionals who provide services in the immediate or long‐term aftermath of traumatic events need to understand the nature and frequency of traumatic events in the lives of women.
Belknap, Ruth Ann, Canaval, Gladys Eugenia, de Bernal, Pilar, Flores, Maria Eugenia Mendoza, Humphreys, Janice Carrol, Jaramillo, Diva, Reeves, Elizabeth, Silva, Susan G., Tiwari, Agnes, Uribe, Tulia   +9 more
core   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source