Results 111 to 120 of about 346,820 (305)

Location of Violent Crime Relative to Trauma Resources in Detroit: Implications for Community Interventions [PDF]

, 2020
Introduction: Detroit, Michigan, is among the leading United States cities for per-capita homicide and violent crime. Hospital- and community-based intervention programs could decrease the rate of violent-crime related injury but require a detailed ...
Abir, Mahshid, Clery, Michael J., Dworkis, Daniel A., Khaldun, Joneigh S., Sonuyi, Tolulope   +4 more
core  

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Suicide: the key role of short range ties

, 2005
The paper explores the connection between short-range social ties (i.e. links with close relatives) and the occurrence of suicide. The objective is to discriminate between a model based on social ties and a model based on psychological traumas.
Roehner, Bertrand M.
core   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

An Assessment of Mental Health Services for Veterans in the State of Texas [PDF]

, 2015
This report describes the complex challenges faced by veterans and their families in seeking, navigating, and attaining adequate mental health care in Texas.
Eaton, David, Hornbach, Rebecca, Marcotte, Lauren, Read, Lindsay   +3 more
core  

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, EarlyView.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

User-Centered Design of Trauma Systems Solutions for Retriage of Patients With Injury: Mixed Methods Study

Journal of Medical Internet Research
BackgroundRetriage is the emergent interhospital transfer of severely injured patients from nontrauma and low-level trauma centers to high-level trauma centers.
John Dwight Slocum, David Jelke, Qixuan Mai, Julie K Johnson, My L T Nguyen, Lixuan Cong, Adithya Chandrasekaran, Jane L Holl, Yuriy Moklyak, Justin Mis, Molly Gabaldo, James G Adams, William M Brigode, Mary Beth Voights, Rebecca Andersen, Tamuriat Gilbert, Nicole Siparsky, Arthur Proust, Anne M Stey, Andrew B L Berry   +19 more
doaj   +1 more source

Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment

Aging and Cancer, EarlyView.
Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey, Murilo Ramos Rocha, Cheyenne Palm, Vania Wang, Denys Balandin, Ethan Black, Kevin Y. Zhang, Fan Huang, Daniel J. Zabransky, Yash Chhabra, Mareike Peters, Gabriel Ghiaur, Ashani Weeraratna   +12 more
wiley   +1 more source

Save the Children's Earthquake Response in Nepal: A Special One-Year Progress Report [PDF]

, 2016
On April 25, 2015 a magnitude-7.9 earthquake hit Nepal affecting millions of families and injuring more than 22,000 people, including children. Whenever a disaster strikes children are the most vulnerable and this disaster was no different.

core  

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source