Results 21 to 30 of about 53,252 (254)

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

FEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira, Sílvia Arroz‐Madeira, Cláudio A. Franco, Sara Silva Pereira   +3 more
wiley   +1 more source

COMMON OCULAR TRAUMA

Journal of the American Medical Association, 1959
Physicians who are not ophthalmologists sometimes are obliged to treat eye injuries either because of the nature of their practice or because the situation demands immediate medical care. The minimum equipment includes some form of magnifier, a source of light, and a treatment tray, the contents of which are here listed. Chemicals splashed into the eye
openaire   +3 more sources

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Animal and bird-related ocular trauma: a decade of experience from a tertiary referral eye hospital of Iran

BMC Ophthalmology
Background This study aimed to explore ocular and periocular injuries resulting from animal and bird attacks among patients referred to a tertiary referral eye hospital of Iran over ten years (2014–2024).
Mohammadreza Mehrabi Bahar, Esmaeil Asadi Khameneh, Hassan Asadigandomani, Alireza Razavi, Seyed Ali Tabatabaei, Zahra Mahdizad, Fatemeh Masoudi Samghabadi   +6 more
doaj   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Demographic characterization and pattern of injury in patients with ocular trauma at the San Ignacio University Hospital in Bogotá, Colombia, during the period 2017–2021

The Pan-American Journal of Ophthalmology, 2023
Introduction: Ocular trauma is an important and preventable cause of decreased vision or blindness. There are just a few studies in Colombia describing the prevalence of ocular trauma in the country.
Sara Margarita Pérez Pérez, Camilo Eduardo Martínez, Paula Moreno, Laura Quintero, Gabriela Escobar, Jacobo Cruz, Juliana Hernández   +6 more
doaj   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Microbial contamination of therapeutic contact lenses after photorefractive keratectomy: a prospective analysis

Journal of Ophthalmic Inflammation and Infection
Purpose The objective of this study was to examine bacterial contamination in therapeutic contact lenses (TCLs) utilized following photorefractive keratectomy (PRK) and to identify factors correlated to positive culture outcomes. Methods This prospective
Mohammad Soleimani, Omid Behjati Najafabadi, Mehrnaz Atighehchian, Alireza Razavi, Zohreh Abedinifar, Seyed Ali Tabatabaei, Hassan Asadigandomani   +6 more
doaj   +1 more source