Results 51 to 60 of about 715,847 (302)

DNA Nanoflower LYTACs Enable Efficient VEGF Degradation and Verteporfin Loading for Combined Therapy of Wet Age‐Related Macular Degeneration

Advanced Science
Wet age‐related macular degeneration (wAMD), characterized by pathological choroidal neovascularization (CNV), is a leading cause of irreversible vision loss in the elderly.
Mengxuan Li, Yan Yue, Sijin Wu, Xinyu He, Jiayi Song, Shuwen Ma, Haokun Zhang, Chenyu Xu, Song Chen, Yanming Huang, Songbo Xie, Hua Yan   +11 more
doaj   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Classification and distribution of ocular trauma by gender.

, 2023
Classification and distribution of ocular trauma by gender.
Frederick Afum Asare (12008835), Moses Jemitara (17095106), Claudio Ngoni Mtuwa (17095109), Michael Agyemang Kwarteng (9992713), Samuel Kyei (9992707)   +4 more
core   +1 more source

Propuesta de una ruta y vía Clínica para el mejoramiento de la calidad en el manejo y tratamiento del trauma ocular contuso basada en la evidencia [PDF]

, 2023
Introducción: El trauma ocular es una causa frecuente de consulta en los servicios de oftalmología, mayormente en el género masculino. Dependiendo de la gravedad del daño ocasionado, el tratamiento representa un reto para el oftalmólogo, porque, se ...
Buitrago Torrado, Manuel Fernando
core   +1 more source

Spatial and Volumetric Characteristics of Glioblastoma: Associations With Clinical Presentation and Survival

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective We aim to comprehensively analyze how regional tumor and edema characteristics are associated with clinical presentations and survival outcomes in a large cohort of glioblastoma patients. Methods Patients with IDH‐wildtype glioblastoma who received brain MRI from 2010 to 2023 were included.
Daniel J. Zhou, Marc Jaskir, Julian Gal, Yombe Fonkeu, Christos Davatzikos, MacLean P. Nasrallah, Jose Garcia, Rubo Xing, Stephen J. Bagley, Arati Desai, Richard E. Phillips, Steven Tobochnik, Colin A. Ellis, James J. Gugger, Nishant Sinha, Joel M. Stein, Kathryn A. Davis   +16 more
wiley   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Trauma ocular [PDF]

, 2017
Esta webaula contempla as principais informações sobre o trauma ocular: Avaliação, tratamento e ...
Núcleo Telessaúde Estadual de Minas Gerais (HC/UFMG), Santos, Daniel Vítor Vasconcelos   +1 more
core  

Comparative analysis of similar hospital-based studies on ocular trauma.

, 2023
Comparative analysis of similar hospital-based studies on ocular trauma.
Frederick Afum Asare (12008835), Moses Jemitara (17095106), Claudio Ngoni Mtuwa (17095109), Michael Agyemang Kwarteng (9992713), Samuel Kyei (9992707)   +4 more
core   +1 more source

Subclinical Optic Nerve Involvement in Radiologically Isolated Syndrome: Multimodal Detection and Diagnostic Impact

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives We aimed to determine the frequency of subclinical optic nerve (ON) lesions using MRI, optical coherence tomography (OCT), and visual evoked potentials (VEP) in radiologically isolated syndrome (RIS), and to assess their diagnostic and prognostic significance.
Christine Lebrun‐Frenay, Cassandre Landes‐Château, Lydiane Mondot, Mikael Cohen, Margherita Popolo, Jérôme de Seze, Bertrand Bourre, Françoise Durand‐Dubief, Olivier Casez, Orhun H. Kantarci, Aksel Siva, Stephanie Baillif, Darin T. Okuda, Letizia Leocani   +13 more
wiley   +1 more source

Notch-1 suppressed ocular trauma injury in ganglion cells via modulating NICD/YAP/EZH2 signaling induced ferroptosis

Scientific Reports
This study aimed to elucidate the role and underlying molecular mechanism of the Notch-1 pathway in regulating ferroptosis in retinal ganglion cells (RGCs) after ocular trauma, focusing on the NICD/YAP/EZH2 signaling axis.
Huipeng Miao, Xinli Jiang, Xiaokun Liu
doaj   +1 more source