Results 51 to 60 of about 72,020 (307)

Ethnic Differences in the Association Between SOD2 rs4880 and Hepatotoxicity in Pediatric Acute Lymphoblastic Leukemia: A Report From the REDIAL Consortium

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Treatment‐associated hepatotoxicity (TAH) is a common complication of pediatric acute lymphoblastic leukemia (ALL) treatment, but genetic risk factors remain poorly understood. We evaluated the SOD2 rs4880 variant in 544 children with ALL at Texas Children's Hospital. After adjusting for demographic and clinical covariates, the rs4880 C allele
Emily J. Mason, John P. Woodhouse, Joanna S. Yi, M. Monica Gramatges, Olga A. Taylor, Veronica A. Morales, Shalini Dhamodharan, Marley Roberts, Karen R. Rabin, Philip J. Lupo, Michael E. Scheurer, Van Huynh, Steven D. Mittelman, Etan Orgel, Austin L. Brown   +14 more
wiley   +1 more source

Quality of pediatric trauma care: development of an age-adjusted TRISS model and survival benchmarking in a major trauma center

Frontiers in Pediatrics
BackgroundPediatric trauma is a major global health concern, accounting for a substantial proportion of deaths and disease burden from age 5 onwards. Effective triage and management are essential in pediatric trauma care, and prediction models such as ...
Ana De los Ríos-Pérez, Ana De los Ríos-Pérez, Alberto Federico García, Alberto Federico García, Paula Gomez, Paula Gomez, Juan José Arias, Juan José Arias, Andrés Fandiño-Losada, Andrés Fandiño-Losada   +9 more
doaj   +1 more source

The Influence of Pain on the Development of PTSD Across the Acute Post Trauma Period [PDF]

, 2018
Exposure to potentially traumatic events is fairly common among US adults, yet only a small fraction develops post-traumatic stress disorder (PTSD). It is unclear, however, why some individuals develop PTSD and others do not.
Connor, Julie P
core   +1 more source

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

Trauma torácico: análise de 124 pacientes submetidos à toracotomia

Revista do Colégio Brasileiro de Cirurgiões
OBJETIVO: Analisar os pacientes submetidos à toracotomia para o tratamento de traumatismo torácico. MÉTODOS: Estudo retrospectivo por meio da análise de prontuários nos dois principais hospitais de referência para trauma em adultos desta cidade, por um ...
Fernando Luiz Westphal, Luiz Carlos de Lima, José Correa Lima Netto, Jeancarllo de Souza da Silva, Vítor Lazarini dos Santos Júnior, Danielle Cristine Westphal   +5 more
doaj   +1 more source

Natural Products as Geroprotective Modulators in Diabetic Nephropathy: A Mechanistic Framework Integrating Aging Hallmarks and the AMPK–SIRT1–Nrf2 Axis

Aging and Cancer, EarlyView.
Natural products target the aging kidney in diabetic nephropathy by restoring the AMPK–SIRT1–Nrf2 axis, reducing oxidative stress, inflammation, fibrosis, and cellular senescence while enhancing mitochondrial biogenesis and antioxidant defenses.
Sherif Hamidu, Latif Adams, Eunice Ampem‐Danso, Justice Kumi, Abigail Aning, Fatima Hamidu, Mustapha Abdul Mumin Mohammed, Ayuba Nii Darku Ankrah, Seth Kwabena Amponsah   +8 more
wiley   +1 more source

Trauma severity predictors

Medicina, 2023
This review aimed to determine which are the indexes for early detection and evaluation of clinical and physiological deterioration of traumatized patients.
André Luís Antoneli Senju, Giovanna Cristina Conti Machado-Kayzuka, Luís Expedito Sabage, Carlos Antonio Negrato, Aguinaldo César Nardi, Cezar Kayzuka Cotta Filho, Alessandra Mazzo   +6 more
doaj  

Trauma Registry: Trauma Quality indicators analysis in hospitalized patients [PDF]

Revista do Colégio Brasileiro de Cirurgiões
Purpose: to consolidate a Trauma Register (TR) trough REDCap data acquisition platform and to validate, in this context, local Quality Indicators (QI) as improvement opportunities in trauma management.
LUCA GIOVANNI ANTONIO PIVETTA, PEDRO DE SOUZA LUCARELLI ANTUNES, GIOVANNA MENNITTI SHIMODA, JOSÉ GUSTAVO PARREIRA, JACQUELINE ARANTES GIANNINNI PERLINGEIRO, JOSE CESAR ASSEF   +5 more
doaj   +1 more source

Re‐Awakening Public Attention to the Silent Pandemic of Cancer Among Older Adults in Low‐ and Middle‐Income Countries

Aging and Cancer, EarlyView.
ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef, Sunkanmi Folorunsho, Abdulazeez Opeyemi Abdulganiyu   +2 more
wiley   +1 more source