Results 151 to 160 of about 262,861 (290)

Protocol Based Standardized Endocrinological Evaluation of Children With Traumatic Brain Injury: A QI Initiative

, 2021
Jayalakshmi Bhat, Ricardo Gómez, Scott Schultz   +2 more
openalex   +1 more source

Targeting Microglial CD49a Inhibits Neuroinflammation and Demonstrates Therapeutic Potential for Parkinson's Disease

Advanced Science, EarlyView.
This study shows that integrin receptor CD49a (Itga1 gene) is significantly upregulated in hyperactivated microglia and microglia‐specific knockdown of Itga1 rescues neuroinflammation and neurodegeneration in a chronic Parkinson's disease (PD) model by targeting PGAM5‐mediated mitochondrial dysfunction and NLRP3 activation. Targeted inhibition of CD49a
Huanpeng Lu, Yunmin Zhu, Xi Wang, Zelin Wu, Zijian Xu, Rongqing Chen, Yanwu Guo   +6 more
wiley   +1 more source

The Role of Interleukins in Pediatric Traumatic Brain Injury: A Narrative Synthesis. [PDF]

J Clin Med
Komiotis C, Mavridis I, Pyrgelis ES, Agapiou E, Meliou M, Birbilis T.   +5 more
europepmc   +1 more source

Esketamine/Ketamine: Dual‐Action Mechanisms and Clinical Prospects beyond Anesthesia in Psychiatry, Immunology, and Oncology

Advanced Science, EarlyView.
Esketamine and ketamine are widely used for perioperative analgesia and anesthesia. Despite their established roles in analgesia, sedation, and anesthesia, as well as emerging antidepressant, anti‐tumor, and anti‐inflammatory effects, their clinical use is limited due to side effects and addiction potential.
Yinxin Wang, Jiangang Xu, Xinyu Zhou, Lu Che, Minghan Qiu, Yang Liu, Ming Gao, Zhen Yang   +7 more
wiley   +1 more source

Introduction. Traumatic brain injury [PDF]

Neurosurgical Focus, 2019
Alex B, Valadka, Andrew I R, Maas, Franco, Servadei   +2 more
openaire   +2 more sources

Disrupting CSPG‐Driven Microglia–Astrocyte Crosstalk Enables Scar‐Free Repair in Spinal Cord Injury

Advanced Science, EarlyView.
This study identifies CSPGs as key drivers of glial scar maturation after spinal cord injury by reprogramming microglial metabolism and inducing astrocyte fibrosis. To address this, a reactive oxygen species‐responsive, reactive astrocyte‐targeted ChABC gene delivery system is designed to locally degrade CSPGs, precisely disrupt maladaptive glial ...
Yufei Zheng, Zhaowei Zhang, Zezhou Fu, Qingqing Wang, Siwen Zhang, Tingyu Zhang, Meifei Zhu, Shunwu Fan, Youqing Shen, Jiajia Xiang, Xin Liu   +10 more
wiley   +1 more source

Crossing the Blood–Brain Barrier with Molecularly Imprinted Polymeric Nanocarriers: An Emerging Frontier in Brain Disease Therapy

Advanced Science, EarlyView.
Molecularly imprinted polymeric nanocarriers (nanoMIPs) offer robust, antibody‐mimetic platforms to overcome the blood‐brain barrier. The article surveys nanoMIP design and ligand‐directed surface engineering that harness receptor‐mediated transcytosis, and highlights therapeutic and diagnostic applications in neurodegeneration, brain tumors and ...
Ranjit De, Shuliang Shi, Kyong‐Tai Kim
wiley   +1 more source

Minutes of Huanhu Academic Symposium on Brain Trauma and Neurocritical Care

Chinese Journal of Contemporary Neurology and Neurosurgery
WANG Xiao⁃hua, ZHANG Guo⁃bin
doaj   +1 more source

The normative modelling framework for traumatic brain injury. [PDF]

Brain
Mitchell JE, McDonald SJ, Sharp DJ, Gan G, Ponsford JL, Marquand A, Wellington C, Law M, Shultz SR, Spitz G.   +9 more
europepmc   +1 more source

Non-Selective Beta-Adrenergic Blocker Propranolol: A Life Saving Drug for Hospitalized Patient with Traumatic Brain Injury in Intensive Care Unit

, 2023
P Ashwathi, K Srinivas
openalex   +2 more sources