Results 201 to 210 of about 570,549 (333)

Chronically Stable, High‐Resolution Micro‐Electrocorticographic Brain‐Computer Interfaces for Real‐Time Motor Decoding

open access: yesAdvanced Science, EarlyView.
A high‐resolution micro‐electrocorticographic (µECoG) brain‐computer interface (BCI) for real‐time motor decoding is reported. The application of flexible, scalable µECoG electrode arrays overcomes the insufficient spatial resolution in conventional ECoG BCIs.
Erda Zhou   +15 more
wiley   +1 more source

Targeting ROCK2 to Restore Epileptic Synaptic Networks via Mitophagy Activation: Insights from Translational Imaging of SV2A In Vivo

open access: yesAdvanced Science, EarlyView.
By integrating synaptic vesicle glycoprotein 2A PET imaging and transcriptomics, this study identifies Rho‐associated protein kinase 2 (ROCK2) as a critical regulator of synaptic network dysfunction in temporal lobe epilepsy. Pharmacological ROCK2 inhibition restores synaptic density and enhances mitophagy, thereby reducing seizures and neuronal damage.
Ling Xiao   +14 more
wiley   +1 more source

Shear Conditioning Promotes Microvascular Endothelial Barrier Resilience in a Human BBB‐on‐a‐Chip Model of Systemic Inflammation Leading to Astrogliosis

open access: yesAdvanced Science, EarlyView.
Physiological flow (0.5 Pa) conditioning promotes resilience of an iPSC‐derived blood–brain barrier endothelium to mild systemic inflammation. In contrast, high “cytokine storm” levels induce barrier breakdown, fibrinogen leakage, and astrocyte activation, reconstituting the two‐hit injury mechanism on‐a‐chip.
Kaihua Chen   +15 more
wiley   +1 more source

Comparative Cochlear Transcriptomics in Echolocating Bats and Mouse Reveals Hras as Protector Against Noise‐Induced Hearing Loss

open access: yesAdvanced Science, EarlyView.
Comparative cochlear transcriptomics of noise‐exposed bats (Miniopterus fuliginosus) and mice reveals bat‐specific protection mechanisms for noise‐induced hearing loss (NIHL), identifying Hras as a key hub regulator. Functional studies in mice show hair‐cell‐specific Hras overexpression significantly reduced hair‐cell damage and NIHL by activating the ...
Peng Chen   +9 more
wiley   +1 more source

Re-evaluating albumin use in traumatic brain injury. [PDF]

open access: yesJ Intensive Care
Vincent JL   +4 more
europepmc   +1 more source

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