Results 201 to 210 of about 824,886 (383)

Traumatic brain injury in the United States; emergency department visits, hospitalizations, and deaths, 2002-2006

, 2010
M. Faul, M. Wald, Likang Xu, V. Coronado
semanticscholar   +1 more source

Single‐Cell Transcriptome Atlas Reveals the Underlying Mechanism of Kynurenic Acid in the Regulation of Tumor Immune Microenvironment in Glioblastoma

Advanced Science, EarlyView.
KYNA regulates the tumor immune microenvironment in glioblastoma. KYNA reprograms the balance between T cell exhaustion and activation to suppress glioblastoma progression through inhibiting exhaustion‐associated markers (such as PD‐1, LAG3, and TOX) and enhancing immune activation and cytotoxicity markers including granzymes GZMA and GZMB.
Di Chen, Liming Sun, Jiajun Chen, Zi Ye, Xuqiang Zhu, Hongjiang Li, Lixin Wu, Guohua Zhao, Qinghao Zhang, Guangyi Jiang, Yuchen Ji, Yake Xue, Hongwei Li, Ruokun Chen, Hongwei Zheng, Rong Zeng, Dongming Yan, Yong Zhang, Xueyuan Li, Jing Yan   +19 more
wiley   +1 more source

Midkine‐Mediated Microglia Activation after Renal Injury Promotes Cognitive Impairment Following Ischemic Renal Injury

Advanced Science, EarlyView.
The mechanism of secondary cognitive impairment following AKI. When renal ischemic injury progresses to fibrosis, renal fibroblasts and damaged tubular cells secrete MDK, which circulates through the bloodstream, crosses the damaged BBB, and accumulates in the hippocampus tissue (an area crucial for learning and memory).
Li Lu, Bixiao Liu, Yu Yang, Tao Meng, Yuanyuan Chang, Yao Peng, Jia Guo, Zhuqing Wang, Hongqian Guo, Liuhua Zhou, Xiaozhi Zhao   +10 more
wiley   +1 more source

Exploration of Novel Biomarkers Through a Precision Medicine Approach Using Multi‐Omics and Brain Organoids in Patients With Atypical Depression and Psychotic Symptoms

Advanced Science, EarlyView.
This study examines major depressive disorder with atypical features and psychotic symptoms through a multi‐omics precision medicine approach. By integrating clinical assessments, WBC scRNA‐seq, plasma proteomics, and brain organoid models, it uncovers immune dysregulation, synaptic protein alterations, and stress‐sensitive neuronal changes.
Insook Ahn, Soyeon Chang, Jiyoung Lee, Seok‐Ho Choi, Jinju Han, Yangsik Kim   +5 more
wiley   +1 more source

Animal models of traumatic brain injury

Nature Reviews Neuroscience, 2013
Y. Xiong, A. Mahmood, M. Chopp
semanticscholar   +1 more source

Gut Bacteria Improve Depressive Symptoms by Degrading Cortisol into Androgen

Advanced Science, EarlyView.
Chronic stress is an important risk factor for stress‐related disorders such as depression. Stress hormone cortisol is essential for the pathogenesis of stress‐related disorders such as depression. Some gut microbiota degraded cortisol, and improve depressive symptoms.
Xiong Wang, Qing Wu, Hao‐Long Zeng, Yin Shen, Hong‐Han Zhang, Jun Gong, Qi Zhang, Jia‐Zhao Xie, Da‐Wei Ye, Zi‐Yong Sun, Zhong‐Chun Liu, Li‐Ming Cheng, Di Li   +12 more
wiley   +1 more source

589 Is there an association between mild traumatic brain injury and subsequent behavioural and/or psychological problems in children under 18 years of age? [PDF]

, 2021
Bindya Sajan
openalex   +1 more source

Dynamic Fibrous Hydrogels for Stem Cell Homing and In Situ Bone Regeneration

Advanced Science, EarlyView.
A dynamic fibrous hydrogel (DFH) is developed by covalent crosslinking of gelatin with tea‐derived trichomes, which integrates the structural and compositional fidelity of native extracellular matrix with photothermal and oxidative responsiveness, introducing a novel “stem cell recruits stem cell” strategy that orchestrates co‐homing of endogenous and ...
Jianmei Chen, Meiling Su, Xinyu Wu, Hongyu Wu, Haotian Wu, Pinghu Zhang, Xueying An, Zongguang Liu   +7 more
wiley   +1 more source

Assessment of verbal and visual episodic memory, post-concussive complaints, and their relathionship following mild traumatic brain injury [PDF]

, 2022
Imene Kochbati, Hélène Audrit, Maude Laguë-Beauvais, Simon Tinawai, de Guise Elaine   +4 more
openalex   +1 more source

Mitochondrial CISD1 Modulates Microglial Metabolic Reprogramming to Drive Stress Susceptibility in Mice

Advanced Science, EarlyView.
CDGSH iron sulfur domain 1 (CISD1) mitigates oxidative stress by promoting NADH oxidation and Coenzyme Q (CoQ) reduction. Under chronic stress, elevated CISD1 expression in microglia enhances NAD⁺ production, thereby increasing GAPDH activity and glycolytic flux, while reducing ATP synthesis by inhibiting proton transfer from mitochondrial complexes I ...
Wanting Dong, Duo Liu, Songsen Fu, Jiaming Zhang, Xi Chen, Songqiang Huang   +5 more
wiley   +1 more source