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Recent advances in traumatic brain injury
Journal of Neurology, 2019 Traumatic brain injury (TBI) is the most common cause of death and disability in those aged under 40 years in the UK. Higher rates of morbidity and mortality are seen in low-income and middle-income countries making it a global health challenge.
Abdelhakim Khellaf, D. Khan, A. Helmy
semanticscholar +1 more source
The Lancet, 2000 The decrease in mortality and improved outcome for patients with severe traumatic brain injury over the past 25 years can be attributed to the approach of "squeezing oxygenated blood through a swollen brain". Quantification of cerebral perfusion by monitoring of intracranial pressure and treatment of cerebral hypoperfusion decrease secondary injury ...
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Longitudinal abnormalities in white matter extracellular free water volume fraction and neuropsychological functioning in patients with traumatic brain injury [PDF]
arXiv, 2022 Traumatic brain injury is a global public health problem associated with chronic neurological complications and long-term disability. Biomarkers that map onto the underlying brain pathology driving these complications are urgently needed to identify individuals at risk for poor recovery and to inform design of clinical trials of neuroprotective ...
arxiv
Links between traumatic brain injury and ballistic pressure waves originating in the thoracic cavity and extremities [PDF]
Brain Injury, Volume 21, Issue 7, June 2007, pages 657-662, 2008 Identifying patients at risk of traumatic brain injury (TBI) is important because research suggests prophylactic treatments to reduce risk of long-term sequelae. Blast pressure waves can cause TBI without penetrating wounds or blunt force trauma. Similarly, bullet impacts distant from the brain can produce pressure waves sufficient to cause mild to ...
arxiv +1 more source
A finite rotation, small strain 2D elastic head model, with applications in mild traumatic brain injury [PDF]
, 2023 Rotational head motions have been shown to play a key role in traumatic brain injury. There is great interest in developing methods to rapidly predict brain tissue strains and strain rates resulting from rotational head motions to estimate brain injury risk and to guide the design of protective equipment. Idealized continuum mechanics based head models
arxiv +1 more source
Neuroenergetics of traumatic brain injury [PDF]
Concussion, 2016 A subset of traumatic brain injury (TBI) patients exhibit cognitive deficits later in life which may be due to the underlying pathology associated with Alzheimer's disease (AD) or chronic traumatic encephalopathy. The similarities between chronic traumatic encephalopathy and AD merit investigation of potentially similar mechanisms underlying the two ...
Zachary M. Weil, Kate Karelina
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Meningeal lymphatic dysfunction exacerbates traumatic brain injury pathogenesis
Nature Communications, 2019 Traumatic brain injury (TBI) is a leading global cause of death and disability. Here we demonstrate in an experimental mouse model of TBI that mild forms of brain trauma cause severe deficits in meningeal lymphatic drainage that begin within hours and ...
Ashley C. Bolte +12 more
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Change in structural brain network abnormalities after traumatic brain injury determines post-injury recovery [PDF]
arXiv, 2022 The trajectory of an individual's recovery after traumatic brain injury (TBI) is heterogeneous, with complete recovery in some cases but persistent disability in others. We hypothesized that changes in structural brain network abnormalities guide the trajectory of an individual's recovery post-injury.
arxiv
JAMA Neurology, 2019 Importance Most traumatic brain injuries (TBIs) are classified as mild (mTBI) based on admission Glasgow Coma Scale (GCS) scores of 13 to 15. The prevalence of persistent functional limitations for these patients is unclear.
L. Nelson +62 more
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A Radiomics Approach to Traumatic Brain Injury Prediction in CT Scans [PDF]
2019 IEEE 16th International Symposium on Biomedical Imaging (ISBI
2019) (pp. 732-735). IEEE, 2018 Computer Tomography (CT) is the gold standard technique for brain damage evaluation after acute Traumatic Brain Injury (TBI). It allows identification of most lesion types and determines the need of surgical or alternative therapeutic procedures. However, the traditional approach for lesion classification is restricted to visual image inspection.
arxiv +1 more source