Results 191 to 200 of about 1,558,604 (252)

Novel approaches for drug development against chronic primary pain: A systematic review

British Journal of Pharmacology, EarlyView.
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus, Éva Borbély, Andreas Goebel, Ralf Baron, Zsófia Hajna, Zsuzsanna Helyes   +5 more
wiley   +1 more source

Symptomatic Management of Sudden Unilateral Severe Spasticity Following a Fall in a Patient With Traumatic Spinal Cord Injury: A Case Report-From Etiology To Symptom-Focused. [PDF]

Clin Case Rep
Dong J, Li Y, Han Y, Zhang F, Li S, Jin L.   +5 more
europepmc   +1 more source

Natural product‐derived TRPM7 channel inhibitors in neurological injury: Mechanisms, pharmacological potential and translational challenges

British Journal of Pharmacology, EarlyView.
Disruption of intracellular ionic homeostasis is a convergent pathological feature across diverse neurological injuries and disorders, including ischaemic and haemorrhagic stroke, hypoxic–ischaemic brain injury, traumatic brain injury, epilepsy and brain tumour.
Xinyang Zhang, Hio Lam Ho, F. David Horgen, Andrea Fleig, Zhong‐Ping Feng, Hong‐Shuo Sun   +5 more
wiley   +1 more source

Follistatin-like Protein 1 Contributes to Acute Traumatic Spinal Cord Injury by Enhancing Neuroinflammation Through the Modulation of Interferon Regulatory Factor 5-Mediated Macrophage Activation. [PDF]

Curr Issues Mol Biol
Luo Y, Ni S, Peng L, Zhu L, Chen T, Wang P, Li Z.   +6 more
europepmc   +1 more source

Cholinergic inputs to motoneurons in the spinal cord augment focal muscle spasticity in rodents

British Journal of Pharmacology, EarlyView.
Background and Purpose Cholinergic premotor inputs to motoneurons support high levels of motor output when required. However, the possible role of these inputs in pathologically elevated muscle tone has not been characterised. To address this, we examined the modulatory effect of spinal acetylcholine (ACh) on experimental spastic paralysis ...
Patrik Meglić, Petra Šoštarić, Eirini Tsape, Melpomeni Galani, Ana Knezović, Laura Restani, Marco Pirazzini, Ornella Rossetto, Gareth B. Miles, Laskaro Zagoraiou, Ivica Matak   +10 more
wiley   +1 more source

3D‐Printed Bioadhesive Interfaces as Proliferative Niches for Tissue Repair

Cell Proliferation, EarlyView.
3D printing transforms bioadhesives into structured, multifunctional interfaces that coordinate adhesion, mechanics, transport and biofunctional signalling and may thereby enable proliferative‐niche formation. Qualifying interfaces support cell survival, context‐appropriate proliferation and constructive remodelling advancing tissue repair towards ...
Zhen Gu, Xinyong Su, Guoshi Xu, Yongqiang Wen, Qi Gu   +4 more
wiley   +1 more source

Role of specialized care in reducing unplanned readmissions after incomplete traumatic spinal cord injury: a population based observational study. [PDF]

BMC Health Serv Res
Rotem-Kohavi N, Xu J, Waheed Z, Fallah N, Bond M, Sutherland JM, Ailon T, Charest-Morin R, Dandurand C, Dea N, Evaniew N, Fisher CG, Paquette S, Street J, Townson A, Vu V, Willms R, Chong M, Noonan VK, Kwon BK, Dvorak MF.   +20 more
europepmc   +1 more source

Combined plasma and imaging biomarkers as predictors of neurological outcome in cervical traumatic spinal cord injury. [PDF]

BMC Neurol
Hei B, Le J, Ding Z, Xu C, Liu Y.
europepmc   +1 more source

The Spinal Muscular Atrophy Functional Classification System

Developmental Medicine &Child Neurology, EarlyView.
The Spinal Muscular Atrophy Functional Classification System (SMAFCS) is a new four‐level functional mobility classification for spinal muscular atrophy, derived from Hammersmith Functional Motor Scale Expanded (HFMSE) thresholds and Functional Mobility Scale (FMS) groupings.
Jason J. Howard, H. Kerr Graham, M. Wade Shrader, Mary Schroth, Manish Kumar, Sadettin Ciftci   +5 more
wiley   +1 more source

Dapsone and N-Acetylcysteine Exert a Synergistic Antinociceptive Effect Associated with Oxidative Stress After Traumatic Spinal Cord Injury: An Isobolographic Study. [PDF]

Brain Sci
Romero-Sánchez HA, Ríos C, Martínez-Cárdenas MLÁ, Navarro L, Moreno-Rocha LA, Mata-Bermudez A, Díaz-Ruiz A.   +6 more
europepmc   +1 more source