Results 121 to 130 of about 662,983 (310)
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Temps de travail et travail du temps
, 2014 MONCHATRE Sylvie, WOEHL Bernard (ed.). Temps de travail et travail du temps. Paris : Publications de la Sorbonne, 2014, 250 p. Comment cerner la portée du travail dans nos existences ?
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A lire : Déni de travail. L'invisibilisation du travail aujourd'hui
, 2012 John Krinsky, Maud Simonet (coord.). "Déni de travail. L'invisibilisation du travail aujourd'hui". Sociétés contemporaines, n° 87, 2013/3, 190 p. John Krinsky et Maud Simonet Déni de travail : l'invisibilisation du travail aujourd'hui. Introduction [
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Molecular Oncology, EarlyView.In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera +11 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
L'école en souffrance : psychodynamique du travail en milieu scolaire /
, 2011 Bibliogr.: p ...
Maranda, Marie-France +2 more
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Images du Travail, Travail des Images : Animaux au travail, travail des animaux
CalendaPour février 2027, la revue Images du Travail – Travail des Images souhaite proposer un numéro sur la tension entre image / travail / animal, en mobilisant de manière ouverte et pluridisciplinaire des ensembles visuels sur le travail ou produit dans le cadre du travail des animaux.
Cailloux, Marianne +2 more
openaire +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source