Results 161 to 170 of about 662,983 (310)

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Université d’été pluridisciplinaire et internationale sur le travail. Santé et travail

, 2018
Le travail est un objet de recherche et de réflexion qui taraude l’humanité en toute période et en tout lieu. Il est au centre des échanges humains; il est un lien économique et social. Il mobilise les sciences techniques, du vivant, humaines et sociales.
Daugareilh, Isabelle, Garrigou, Alain, Lerouge, Loïc   +2 more
core  

Promouvoir le bien-être des médecins membres du personnel au Canada. [PDF]

CMAJ
Do V, Lewis M, Li H.
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Étude sur les sanctions et mesures correctives de l'inspection du travail : le cas de la France

, 2011
http://www.ilo.org/labadmin/what/pubs/WCMS_157718/lang--fr/index.htmLes moyens et l'organisation de l'inspection du travail ont fortement évolué ces dernières années en France. Il n'en va pas tout à fait de même du système de sanctions des infractions au
Auvergnon, Philippe
core  

Experimentally recreated workplace environments contain submicron crystalline silica particles, including ultrafine particles, which have been identified in the mediastinal lymph nodes of construction workers. [PDF]

Occup Environ Med
Bazin D, Bressot C, Colboc H, Meunier L, Begueret H, Bachmeyer A, Heng-Pradere TT, Tranca I, Rodriguez F, Tielens F, Tang E, Audouin C, Letavernier E, Cambrelin M, Bernaudin JF, Brochard P.   +15 more
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Observer le travail

, 2015
Comment les problématiques de santé psychique au travail participent-elles au renouvellement de la manière d’observer et d’analyser le travail ? Première séance du séminaire du Réseau Jeunes Chercheurs Travail et Santé (RJCTS) Le mardi 6 octobre 2015 à l'
Rédaction
core  

Thrombopénie récurrente avec agrégation plaquettaire chez une femme enceinte. [PDF]

CMAJ
Khalife R, Mahdi T, Tinmouth A.
europepmc   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source