Results 51 to 60 of about 662,983 (310)

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Le programme ANR COW : l'ouverture d'un front de recherches inédit sur le travail animal

Natures Sciences Sociétés, 2017
Les animaux travaillent-ils ? C'est la question qu'a posée le programme ANR COW (2012-2016). En rupture avec l'idée que le travail est un propre de l'homme, nous avons fait l'hypothèse que les animaux étaient aussi des acteurs du travail et qu'il était ...
Porcher Jocelyne
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Émotions au travail, travail des émotions : présentation du corpus

, 2015
International audienceLe travail, qui occupe une place centrale dans nos sociétés, sollicite sans cesse les émotions. Au cœur des rapports sociaux et des conflits, il engendre tout à la fois violence ou solidarité, suscitant des sentiments d’injustice ...
Sabine Fortino, Fortino, Sabine, Aurélie Jeantet, Albena Tcholakova, Tcholakova, Albena, Jeantet, Aurelie   +5 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Mobilité internationale en Europe centrale  touristes, commerçants et migrants

Revue Européenne des Migrations Internationales, 2002
International Mobility in Central Europe: Tourists, Traders and Migrants. -- Central Europe has been typical for a high volume of international travel, which further increased during transition period. This paper analyses particular kinds of cross-border
Allan M. Williams, Vladimír Balá
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Livre blanc du travail social 2023 [PDF]

Jamais dans son histoire le secteur du travail social n’a connu une crise d’attractivité aussi intense. Les difficultés de recrutement sont majeures tant pour les employeurs que dans les écoles de formation. Cette tendance est à l’oeuvre depuis longtemps
Haut Conseil du travail social
core  

Pour une histoire du travail !

Cahiers d’histoire, 2014
L’Association française pour l’histoire des mondes du travail (AFHMT) a été constituée le 15 juin 2013. Cette nouvelle structure, initiée par Nicolas Hatzfeld, Michel Pigenet et Xavier Vigna, rencontre aujourd’hui un vif succès auprès de la communauté ...
David Hamelin
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source