Results 71 to 80 of about 1,192,546 (315)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
A sociologia: ciência e ofício
Educação & Sociedade, 2012 A autora analisa aqui os principais aspectos da evolução do ofício de sociólogo. Para tanto, parte da sua experiência em sociologia nas fronteiras da educação e do trabalho e da revisão de um vasto corpus de arquivos oriundos de diversas fontes ...
Lucie Tanguy
doaj +1 more source
Don’t tell us: the demand for secretive behaviour [PDF]
The matter studied here is how, and with what implications, people may decide that they do not want to be let into secrets that concern them. They could get the information at no cost but they refuse to know.
Pierre Salmon
core
Étude sur Les Perceptions et les Attentes des Professionnels de Santé, des Bénévoles et des Familles des Malades dans le Cadre de la Prise en Charge des Soins Palliatifs [PDF]
, 2008 This qualitative study, conducted in three metropolitan areas, Champagne Ardenne, Ile-de-France, and Languedoc-Roussillon explores current palliative care practices in 37 facilities, both for dependent elderly (nursing homes) and for adults and children ...
Brigitte Haury, Muriel Moisy
core
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Il lavoro gravemente sfruttato degli immigrati. Una ricerca condotta a Roma e nell’Agro Pontino
Italies, 2010 Questo saggio analizza le modalità di inserimento lavorativo degli immigrati per individuarne i motivi e le radici del grave sfruttamento. Il nucleo di queste problematiche è costituito dalla precarietà delle condizioni giuridiche e dal forte isolamento ...
Federica Dolente
doaj +1 more source
'God was with me in a wonderful manner':the Puritan origins of the Indian captivity narrative [PDF]
, 2012 This paper argues that the origins of the Indian captivity narrative should be understood in the historical contexts of its production in the New World as a narrative that is at once descriptive of the personal experiences of frontier captives of the ...
Panay, Andrew
core
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source