Results 71 to 80 of about 450,972 (302)
مجلة جامعة دمشق للآداب و العلوم الإنسانيةDans ce travail, nous traiterons l’idée de la présence effective, réelle, et explicite de l’auteur dans son œuvre. Cette idée sera traitée à travers trois points.
Mohammad Meraai Hasan Atmeh +1 more
doaj
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Pour une histoire du travail !
Cahiers d’histoire, 2014 L’Association française pour l’histoire des mondes du travail (AFHMT) a été constituée le 15 juin 2013. Cette nouvelle structure, initiée par Nicolas Hatzfeld, Michel Pigenet et Xavier Vigna, rencontre aujourd’hui un vif succès auprès de la communauté ...
David Hamelin
doaj +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
La radicalité du manger chez Levinas
Journal of French and Francophone PhilosophyLe texte propose une analyse de l'acte de manger chez Emmanuel Levinas. Plus spécifiquement, nous nous concentrons sur le manger et le travail. Le manger et le travail sont deux types d’appropriation possibles du monde par l’ipséité.
Alžbeta Kuchtová, Rui Matsuba
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Cahiers AgriculturesLes oasis de montagne d’Afrique du Nord subissent de plein fouet les effets du changement climatique, qui amplifient l’ensemble des contraintes agronomiques : foncier exigu, aridité structurelle, etc.
Sraïri Mohamed Taher, Amartini Hakim
doaj +1 more source
DU NORMATIVISME SYMBOLIQUE A L’APPARITION DE L’ECONOMIE D’ACCUMULATION AU NEOLITHIQUE [PDF]
Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2010 Le problème de la néolithisation, considérée, dès 1929 par Gordon Childe, comme la deuxième grande révolution, après celle de l’anthropogenèse, est loin d’être un chapitre clos des sciences de l’homme.
Dan SEMENESCU
doaj