Results 81 to 90 of about 927,330 (306)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Intermediality, Multimodality and Medial Chronotopes: A Comparison between the Travel Book and the Travel Blog

open access: yesCaracteres: Estudios Culturales y Críticos de la Esfera Digital, 2014
Using Bakhtin’s “chronotope”, this paper advances a comparison between the travel book Il mondo oltre il fiume dei peschi in fiore by Sino-Italian Bamboo Hirst and the travel blog Emil’s Trip to China, by American Emil Kang.
Stefano Calzati
doaj  

Visualization and real-time fluorescence RPA detection methods for enterohemorrhagic Escherichia coli O157:H7

open access: yesZhongguo shipin weisheng zazhi
ObjectiveTo detect enterohemorrhagic Escherichia coli (EHEC) O157:H7, visualization recombinant enzyme polymerase amplification (RPA) detection and real-time fluorescence RPA detection methods were established based on RPA technology.MethodsPrimers and ...
XU Ying   +3 more
doaj   +1 more source

A clinical quiz that turns heads

open access: yesSouth African Family Practice, 2007
This column is aimed at developing your clinical acumen. A clinical quiz will alternate with a short discussion of a clinical sign. You are invited to send us requests for future topics and to provide photographs of clinical signs for the quiz section ...
Richard Foster
doaj   +1 more source

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

COVID-19 severity and corticosteroid treatment have minimal effect on specific antibody production

open access: yesBMC Infectious Diseases
Background Dexamethasone is currently administered for Coronavirus disease 2019(COVID-19); however, there are concerns about its effect on specific antibodies’ production. The aim of this study was to evaluate whether specific antibodies were affected by
Takato Nakamoto   +16 more
doaj   +1 more source

Storytelling: Developing stories and experiences more on food tourism

open access: yesInternational Journal of Applied Sciences in Tourism and Events
Food tourism has become one of the main attractions in the era of globalization, especially in Indonesia, with the growth of the food tourism sector continuing to develop.
Handayani Rahayuningsih   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

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