Results 71 to 80 of about 80,460 (262)

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Gender and Age in the Travel Choice by Spanish Travel Agency Consumers

open access: yesSocieties
The tourist intermediary industry has faced multiple challenges to adapt their offers to the heterogeneity of tourists, and understanding consumer interests from a gender and age perspective is considered crucial in the design and marketing of tourist ...
Ángel Rodríguez-Pallas   +3 more
doaj   +1 more source

Undoing one’s past

open access: yesFilosofia Unisinos, 2018
In contemporary research on memory, the idea of mental time travel (MTT) has been connected, at the functional level, with planning and imagining what might occur in one’s future.
Eduardo Vicentini de Medeiros
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

The Travel Agency Website – Factor for Business Success [PDF]

open access: yesOvidius University Annals: Economic Sciences Series, 2017
E-commerce is a constant of contemporary life. The online purchase of tourist products is a complex and delicate process, and in this respect, the website has a decisive role.
Băltescu Codruța Adina
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

ISLAMIC BUSINESS ETHICS IMPLEMENTATION IN MARKETING COMMUNICATION OF HAJJ/UMROH TARVEL AGENCY “X” SURABAYA

open access: yesAl-Iqtishad: Jurnal Ilmu Ekonomi Syariah, 2016
Nowadays people consider ethics separately in business activities. Therefore, there are so many ethic breaches done by companies, including hajj/umroh travel agency. It is proven by the fact of  many pilgims who were failure to have hajj in 2014.
Ari Prasetyo, Intan Kusuma Pratiwi
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

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