Results 141 to 150 of about 213,940 (301)

Investigating influencing factors for ICT adoption that changes travel behavior in response to the COVID-19 outbreak in Indonesia. [PDF]

Case Stud Transp Policy, 2023
Rizki M, Joewono TB, Irawan MZ, Belgiawan PF, Bastarianto FF, Prasetyanto D.   +5 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Test of the relation between travel and activities times : different representations of a demand derived from activity participation [PDF]

The paper tests linear and non-linear specifications of the relationship between travel times and activity times, in 4 four French and three Swiss cities, observed at two different periods. First, following Kitamura et al.
Joly, I.
core  

Analyzing the Impact of COVID-19 on Travel and Search Distances for Prominent Landmarks: Insights from Google Trends, X, and Tripadvisor

Geographies
The COVID-19 pandemic profoundly affected people’s travel behavior and travel desires, particularly regarding trips to prominent destinations. This study explores the pandemic’s impact on travel behavior and online search patterns for 12 landmarks across
Jiping Cao, Hartwig H. Hochmair, Andrei Kirilenko, Innocensia Owuor   +3 more
doaj   +1 more source

Understanding individual-level travel behavior changes due to COVID-19: Trip frequency, trip regularity, and trip distance. [PDF]

Cities, 2023
Lee S, Ko E, Jang K, Kim S.
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

An Agent-based Route Choice Model [PDF]

Travel demand emerges from individual decisions. These decisions, depending on individual objectives, preferences, experiences and spatial knowledge about travel, are both heterogeneous and evolutionary. Research emerging from fields such as road pricing
Shanjiang Zhu, Lei Zhang, David Levinson
core  

Subjective variables in travel behavior models: a critical review and Standardized Transport Attitude Measurement Protocol (STAMP). [PDF]

Transportation (Amst), 2022
Bhagat-Conway MW, Mirtich L, Salon D, Harness N, Consalvo A, Hong S.   +5 more
europepmc   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source