Results 141 to 150 of about 1,167,337 (295)

Health Impacts of the Built and Social Environments, and Travel Behavior: The Case of the Sunshine State. [PDF]

Int J Environ Res Public Health, 2022
Mahmoudi J, Zhang L.
europepmc   +1 more source

Terrorism and Tourism in the Asia Pacific Region: Is Travel and Tourism in a New World After 9/11? [PDF]

The paper reviews trends in travel and tourism in selected Asia Pacific countries before and after the terrorist attacks of September 11, 2001 (9/11) to consider the question of whether or not global tourism has fundamentally changed since 9/11.
Christopher Edmonds, James Mak
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Analyzing the Impact of COVID-19 on Travel and Search Distances for Prominent Landmarks: Insights from Google Trends, X, and Tripadvisor

Geographies
The COVID-19 pandemic profoundly affected people’s travel behavior and travel desires, particularly regarding trips to prominent destinations. This study explores the pandemic’s impact on travel behavior and online search patterns for 12 landmarks across
Jiping Cao, Hartwig H. Hochmair, Andrei Kirilenko, Innocensia Owuor   +3 more
doaj   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Understanding individual-level travel behavior changes due to COVID-19: Trip frequency, trip regularity, and trip distance. [PDF]

Cities, 2023
Lee S, Ko E, Jang K, Kim S.
europepmc   +1 more source

Demand for Vacations /Travel in Protected Areas – Dimension of Tourists’ Ecological Behavior [PDF]

Tourism, in itself, is one of the main users of the environment and, implicitly, an important contributor to its deterioration. Intensification of tourist travel will naturally generate an increase of the negative environmental impacts and, in the long ...
Delia Popescu, Mihaela Pădurean, Remus Hornoiu, Rodica Minciu   +3 more
core  

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Subjective variables in travel behavior models: a critical review and Standardized Transport Attitude Measurement Protocol (STAMP). [PDF]

Transportation (Amst), 2022
Bhagat-Conway MW, Mirtich L, Salon D, Harness N, Consalvo A, Hong S.   +5 more
europepmc   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

Molecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak, Iva Staniczková Zambo, Matěj Přikryl, Peter Múdry, Danica Zapletalová, Jarmila Navrátilová, Jiří Navrátil, Jan Šmarda, Liudmyla Drobot, Petr Beneš, Lucia Knopfová   +10 more
wiley   +1 more source