Results 71 to 80 of about 990,169 (288)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Cost-effectiveness analysis of malaria chemoprophylaxis for travellers to West-Africa [PDF]

, 2010
Background: The importation of malaria to non-endemic countries remains a major cause of travel-related morbidity and a leading cause of travel-related hospitalizations. Currently they are three priority medications for malaria prophylaxis to West Africa:
Widmer, Lukas L, Blank, Patricia R, Van Herck, Koen, Hatz, Christoph, Schlagenhauf, Patricia   +4 more
core   +3 more sources

Antimicrobial Resistance Trends, Resistance Mechanisms, and Antibiotic Consumption in COVID-19 Versus Non-COVID-19 Units: A Seven-Year Retrospective Cohort Study

Antibiotics
Background: The COVID-19 pandemic profoundly affected healthcare delivery and antibiotic prescribing, raising concerns about increasing antimicrobial resistance.
Stefan Porubcin, Alena Rovnakova, Ondrej Zahornacky, Pavol Jarcuska   +3 more
doaj   +1 more source

23rd Annual Meeting of the German Professional Association of Travel Medicine (DFR) Coburg, Germany, 18-19. September 2020

Health Promotion & Physical Activity, 2020
The publication contains summaries of papers presented at the annual meeting of German Professional Association of Travel Medicine (DFR) • J. Hinkelbein: In-flight Medical Emergencies (IFME) • N.
Günter Schmolz
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Commodity culture : tropical health and hygiene in the British Empire [PDF]

, 2008
Before heading to a 'tropical' region of the Empire, British men and women spent considerable time and effort gathering outfit believed essential for their impending trip.
Johnson, Ryan
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

3. Travel medicine—prevention based on epidemiological data [PDF]

, 2017
In travel medicine efforts should be concentrated on preventive measures that are necessary, and travellers should be spared the side effects, costs and stress of superfluous measures.
Steffen, Robert
core  

Requests for malaria prevention advice to Public Health England, Malaria Reference Laboratory: a retrospective observational study.

, 2013
BACKGROUND: The Malaria Reference Laboratory (MRL) provides a specialist advisory service for complex queries from healthcare professionals. This study was conducted to examine the types of queries that general practitioners and nurses ask around malaria
Blaze, Marie, Chiodini, Peter L, Godbole, Gauri, Smith, Valerie, Whitty, Christopher JM   +4 more
core   +1 more source