Results 111 to 120 of about 609,544 (306)

Investigating the distribution of the value of travel time savings [PDF]

open access: yes
The distribution of the value of travel time savings (VTTS) is investigated employing various nonparametric techniques on a large, high quality data set.
Mogens Fosgerau
core  

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Using hexagonal grids and network analysis for spatial accessibility assessment in urban environments – a case study of public amenities in Toruń

open access: yesMiscellanea Geographica: Regional Studies on Development, 2019
Spatial accessibility is one of fundamental problems of geography, and transport geography in particular. It is one of the key factors affecting the ability to use certain services by the residents of a given area.
Burdziej Jan
doaj   +1 more source

The cost of bus travel time variability [PDF]

open access: yes, 2006
The reliability of bus systems is a vital issue on the transport agenda, since urban areas are yearning for high quality alternatives for the private car. A key indicator of reliability is a low level of day-to-day travel time variability (TTV).
Hollander, Yaron
core  

Almanacs, Polytemporality, and Early Modern Travel

open access: yes, 2020
This chapter critically examines printed almanacs for what they can tell us about early modern English attitudes towards time, temporality, and travel.
Margaret R. Hunt, Hunt, Margaret R.,
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Variability versus stability in daily travel and activity behaviour. The case of a one week travel diary [PDF]

open access: yes
Temporal rhythms in travel and activity patterns are analysed thanks to a seven-day travel diary collected on 707 individuals in the city of Ghent (Belgium) in 2008.
Charles Raux, Eric Cornelis, Tai-Yu Ma
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Valuation of uncertainty in travel time and arrival time - some findings from a choice experiment [PDF]

open access: yes
We are developing a dynamic modeling framework in which we can evaluate the effects of different road pricing measures on individual choice behavior as well as on a network level.
Michiel Bliemer, Dirk Van Amelsfort
core  

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