Results 91 to 100 of about 609,544 (306)
Implementing Time Travel for the Web
Code4Lib Journal, 2011 This article discusses the challenges and solutions discovered for implementing the Memento protocol in a variety of browser environments. It describes the design and deployment of the client technologies which have been developed: a web application that
Robert Sanderson +4 more
doaj
Time-Traveling Rules of Interpretation: Of ‘Time-Will’ and ‘Time-Bubbles’
SSRN Electronic Journal, 2020 International courts and tribunals are fond of paying lips service to the fact that Articles 31-33 of the Vienna Convention on the Law of Treaties (VCLT) reflect customary international law. This allows them to draw inspiration from the text of the VCLT even in cases where a treaty that is being interpreted was concluded either before 1980 (the date of
openaire +1 more source
Trends in commuter and leisure travel in The Netherlands 1991-2001 - Mode choice and travel time [PDF]
Data collected over recent years indicates that there has been an increase in the average distance of trips made, in the Netherlands (e.g. in 1985 the average trip made was 8.7 km, in 2000 the average trip length was 10.6 km (Harms, 2003)).
Christy Collins, Arianne De Blaeij
core
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
SPECIFICATION OF A MODEL TO MEASURE THE VALUE OF TRAVEL TIME SAVINGS FROM BINOMIAL DATA [PDF]
Using nonparametric methods, the paper examines the specification of a model to evaluate the distribution of willingness-to-pay (WTP) for travel time savings from binomial choice data from a simple time-cost trading experiment involving four public ...
Mogens Fosgerau
core +2 more sources
Illusion of Motion: Variation of Subjective Value of Travel Time on Freeways and Ramp Meters [PDF]
This paper explores drivers' subjective value of time under moving and stopped freeway travel conditions using a stated preference survey. Unlike previous studies that assume a constant value of time, this research relates perceived satisfaction of a ...
Feng xie, Lei Zhang, David Levinson
core
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source