Results 71 to 80 of about 14,783,662 (197)

Understanding temporal rhythms and travel behaviour at destinations: Potential ways to achieve more sustainable travel [PDF]

, 2013
This paper analyses the roles played by time in destination-based travel behaviour. It contrasts clock time's linear view of time with fragmented time, instantaneous time, fluid time and flow, time out and the multiple temporalities of tourism ...
Norgate, S., Filimonau, V, Filimonau, Viachaslau, Winstanley, C, Norgate, Sarah, Winstanley, C., Cherrett, Tom, Cherrett, T., Winstanley, Chris, Norgate, SH, Davies, N, Cherrett, T, Davies, Nigel, Dickinson, JE, Speed, Chris, Davies, N., Dickinson, Janet E., Speed, C, Speed, C.   +18 more
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Experiencing pleasantness vs. unpleasantness of daily travel – Exploring gendered travel time use and non-travel dimensions in Germany

European Transport Studies
A recent strand of literature in transportation research focuses on understanding the effects of trip characteristics and travel-related attitudes on travel satisfaction. To date, hardly any studies focus on the effect of gendered travel time use and non-
Bhuvanachithra Chidambaram, Joachim Scheiner   +1 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

The role of travel time budgets – Representation of a demand derived from activity participation [PDF]

The paper exams the relationships between travel and activity times, in 7 travel surveys from 4 French and 3 Swiss cities, observed at two different periods.
Iragaël Joly
core  

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Implementing Time Travel for the Web

Code4Lib Journal, 2011
This article discusses the challenges and solutions discovered for implementing the Memento protocol in a variety of browser environments. It describes the design and deployment of the client technologies which have been developed: a web application that
Robert Sanderson, Harihar Shankar, Scott Ainsworth, Frank McCown, Sam Adams   +4 more
doaj  

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source