Results 61 to 70 of about 14,783,662 (197)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Cancer Medicine, 2020 Introduction There is limited evidence on the impact of centralization of cancer treatment services on patient travel burden and access to treatment. Using prostate cancer surgery as an example, this national study analysis aims to simulate the effect of
Ajay Aggarwal +4 more
doaj +1 more source
Commuters’ valuation of travel time variability in Barcelona [PDF]
The value given by commuters to the variability of travel times is empirically analysed using stated preference data from Barcelona (Spain). Respondents are asked to choose between alternatives that differ in terms of cost, average travel time ...
Anna Matas, Javier Asensio
core
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Sustainable Development Commission’s commentary on JMP’s 2009 report : a review of Government travel [PDF]
, 2012 This document is a response to 'A review of Government travel : sustainable travel engaging the public sector'.We have commented on JMP’s report A Review of Government Travel, which was commissioned jointly by the Sustainable Development Commission and ...
Sustainable Development Commission
core +2 more sources
Analyzing the Accessibility to Primary Health Care Centers Using Geographic Information Systems: A Case Study of Tangier [PDF]
E3S Web of ConferencesPrimary Health Care (PHC) is a pillar of any health care system, significantly enhancing population health through improved access and quality of care. This study utilizes Geographic Information System (GIS) tools to examine the spatial accessibility of ...
Bahmane Soukaina +3 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
The link between travel Time Budget and Speed: a Key relationship for urban space-time dynamics [PDF]
The relationship between travel time budget (TTB) and speed is central to transport economics and allows us to analyze travel behaviour, urban structure and the transport system.
Iragaël Joly
core
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Travel Time Budget – Decomposition of the Worldwide Mean [PDF]
The paper is concerned with the travel activity and more specifically the urban travel time during a day. This individual mean travel time budget (TTB) has been hypothesised by Zahavi (1980) to be a constant amount of time close to 1 hour per day.
Iragaël Joly
core