Results 81 to 90 of about 14,783,662 (197)
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Applied Sciences(1) Background: Rapid urban growth in China has extended rail systems to neighboring cities to meet intercity travel needs, making it important to understand intercity travel patterns.
Yao Xie +4 more
doaj +1 more source
Imaging the Mediterranean upper mantle by p- wave travel time tomography
Annals of Geophysics, 1997 Travel times of P-waves in the Euro-Mediterranean region show strong and consistent lateral variations, which can be associated to structural heterogeneity in the underlying crust and mantle.
A. Morelli, C. Piromallo
doaj +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Unit income elasticity of the value of travel time savings [PDF]
The paper presents an analysis of the income elasticity of the value of travel time savings (VTTS). It expands on previous micro-econometric estimates of the VTTS on binary choice experimental data by accounting for income taxes, for the dependence of ...
Mogens Fosgerau
core
Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding
FEBS Letters, EarlyView.In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança +2 more
wiley +1 more source
Miscellanea Geographica: Regional Studies on Development, 2019 Spatial accessibility is one of fundamental problems of geography, and transport geography in particular. It is one of the key factors affecting the ability to use certain services by the residents of a given area.
Burdziej Jan
doaj +1 more source
Translophagy—A potential link between autophagy impairment and translational errors
FEBS Letters, EarlyView.Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk +11 more
wiley +1 more source
Stability or regularity of the daily travel time in Lyon? Application of a duration model [PDF]
Escaping unidimensional analysis limits and linear regression irrelevancy, the duration model incorporates impacts of covariates on the duration variable and permits to test the dependence of daily travel times on elapsed time.
Iragaël Joly
core