Results 111 to 120 of about 2,716,785 (324)

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Using License Plate Recognition Data to Gain Insight into Urban Travel Time Distributions

Journal of Highway and Transportation Research and Development
Travel time distribution is an essential tool for measuring urban traffic performance, a subject that has been studied for decades. This paper conducts a comprehensive investigation of two types of travel time distributions using extensive license plate ...
Xiaoqin Luo
doaj   +1 more source

Travel Time Shifts due to Amplitude Modulation in Time-Distance Helioseismology

, 2009
Correct interpretation of acoustic travel times measured by time-distance helioseismology is essential to get an accurate understanding of the solar properties that are inferred from them. It has long been observed that sunspots suppress p-mode amplitude,
A. G. Kosovichev, Chou, Gradshteyn, Jackson, Kosovichev, Nigam, Parchevsky, R. Nigam, Rajaguru, Zhao   +9 more
core   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Uncovering the Uncertainties and Variability of Travel Time and Fuel Consumption Using Floating Car Data: A Case Study in Wuhan

IEEE Access
Understanding the probabilistic behavior of both travel time and fuel consumption is critical for improving urban traffic efficiency and developing reliable urban transportation systems.
Wenxin Teng, Fei Liu, Jianbing Yang, Chaoyang Shi, Yunfei Zhang, Fuqiang Wang   +5 more
doaj   +1 more source

Valuation of uncertainty in travel time and arrival time - some findings from a choice experiment [PDF]

We are developing a dynamic modeling framework in which we can evaluate the effects of different road pricing measures on individual choice behavior as well as on a network level.
Dirk Van Amelsfort, Michiel Bliemer
core  

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Analytical Model for the Change of Travel Time Savings With Waiting Time and Service Level

IEEE Access, 2019
An extended classical time allocation model with travel time reliability constraint is proposed in this study. The valuation function of travel time savings is deduced, and the relationship between the value of travel time savings and other social ...
Junjie Zhang, Xiaoya Xu, Haiyang Yu, Miaomiao Liu, Can Yang   +4 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source