Results 41 to 50 of about 232,364 (262)
Complex & Intelligent Systems, 2022 AbstractThis paper presents a novel integrated distributed production and distribution scheduling problem in group manufacturing with uncertain travel time (IDPDSP-GM-UTT), in which products are firstly produced in several distributed hybrid flow shops and then delivered to several retailers in batches.
Jun Guo 0012 +3 more
openaire +3 more sources
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Travel Time Probability Prediction Based on Constrained LSTM Quantile Regression
Journal of Advanced Transportation, 2023 Travel time reliability assessment has been widely used in recent years to evaluate the performance of transportation networks and measure the operation level of transportation systems.
Hao Li +5 more
doaj +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley +1 more source
A Departure Time Choice for Morning Commute Considering Train Capacity of a Rail Transit Line
Advances in Mechanical Engineering, 2013 Every commuter utilizing urban rail transit decides the departure time from home to a station according to individual judgment for the biggest possibility to board a train as soon as possible after the arrival.
Jia Feng +4 more
doaj +1 more source
Estimating Travel Time Distribution under Different Traffic Conditions
Transportation Research Procedia, 2014 AbstractIncreasing mobility and congestion results in an increase in travel time variability and in a decrease in reliability. Reliability becomes an important performance measure for transportation facilities. A variety of performance measures have been proposed to quantify it. Many of these indicators are based on percentiles of travel time.
Guessous, Younes +3 more
openaire +3 more sources
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Journal of Advanced Transportation, 2018 Exploring travel time distribution and variability patterns is essential for reliable route choices and sophisticated traffic management and control. State-of-the-art studies tend to treat different types of roads equally, which fails to provide more ...
Peng Chen +3 more
doaj +1 more source