Results 61 to 70 of about 20,101,928 (317)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
An Improved Tabu Search Algorithm for the Stochastic Vehicle Routing Problem With Soft Time Windows
IEEE Access, 2020 In real-world environments, vehicle travel and service time will be affected by unpredictable factors and present a random state. Because of this situation, this article proposes the vehicle routing problem with soft time windows and stochastic travel ...
Guoming Li, Junhua Li
doaj +1 more source
Estimation of Bimodal Urban Link Travel Time Distribution and Its Applications in Traffic Analysis
, 2015 Vehicles travelling on urban streets are heavily influenced by traffic signal controls, pedestrian crossings, and conflicting traffic from cross streets, which would result in bimodal travel time distributions, with one mode corresponding to travels ...
Yu-Xiong Ji +3 more
semanticscholar +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
A Departure Time Choice for Morning Commute Considering Train Capacity of a Rail Transit Line
Advances in Mechanical Engineering, 2013 Every commuter utilizing urban rail transit decides the departure time from home to a station according to individual judgment for the biggest possibility to board a train as soon as possible after the arrival.
Jia Feng +4 more
doaj +1 more source
PLoS ONE, 2017 Introducing electric vehicles (EVs) into urban transportation network brings higher requirement on travel time reliability and charging reliability. Specifically, it is believed that travel time reliability is a key factor influencing travelers' route ...
Rui Zhang, Enjian Yao, Yang Yang
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
Barekeng, 2020 Distribution is a delivery of goods from an original area to the destination area, wherein the distribution, the problem of travel routes is very important because it can affect the time and cost of doing the distribution.
Jemsry E. Lakotany +2 more
doaj +1 more source
Catchment mixing processes and travel time distributions [PDF]
Water Resources Research, 2012 This work focuses on the description and the use of the probability density functions (pdfs) of travel, residence and evapotranspiration times, which are comprehensive descriptors of the fate of rainfall water particles traveling through catchments, and provide key information on hydrologic flowpaths, partitioning of precipitation, circulation and ...
openaire +2 more sources