Results 71 to 80 of about 151,942 (250)

Impact of connected and automated vehicles on the travel time reliability of an urban network

International Journal of Transportation Science and Technology
Connected and automated vehicles (CAVs) have the potential to revolutionise the transportation industry, with a plethora of research already revealing considerable gains in safety, travel time and mobility, as well as reduced congestion and pollution. As
Shehani Samaranayake, Sai Chand, Amolika Sinha, Vinayak Dixit   +3 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Estimating uncertainty and Misery (Index) of the paratransit experience

Transportation Research Interdisciplinary Perspectives
Transportation access significantly impacts inclusion, well-being, and health. However, people with disabilities often struggle to use fixed-route transit due to mobility challenges.
Aditi Misra, Wesley Marshall, Lucy O’Sullivan, Molly Wagner, Manish Shirgaokar   +4 more
doaj   +1 more source

Data analytics approach for travel time reliability pattern analysis and prediction

Journal of Modern Transportation, 2019
Travel time reliability (TTR) is an important measure which has been widely used to represent the traffic conditions on freeways. The objective of this study is to develop a systematic approach to analyzing TTR on roadway segments along a corridor.
Zhen Chen, Wei Fan
doaj   +1 more source

Haemophagocytic lymphohistiocytosis complicating visceral leishmaniasis in the UK: a case for detailed travel history, a high index of suspicion and timely diagnostics

BMJ Case Reports, 2019
A 4-month-old male infant presented acutely unwell with fever. He was initially treated for sepsis but failed to improve with IV broad spectrum antibiotics. Haemophagocytic lymphohistiocytosis (HLH) was diagnosed due to his fever, pancytopenia, splenomegaly, hypertriglyceridaemia, hypofibrinogenaemia and significant hyperferritinaemia.
Sarah May Johnson, Kimberly Gilmour, Sujith Samarasinghe, Alasdair Bamford   +3 more
openaire   +3 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Disparities in ridehailing travel times for accessing non-work destinations

Transportation Research Interdisciplinary Perspectives
We contribute to the literature on new mobilities by measuring spatial disparities in travel times for accessing essential non-work destinations via ridehailing. We focused on healthcare, restaurants, and grocery destinations in Chicago.
Sicheng Wang, Robert B. Noland, Xiao Huang   +2 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Origin-Destination-Based Travel Time Reliability under Different Rainfall Intensities: An Investigation Using Open-Source Data

Journal of Advanced Transportation, 2020
Origin-destination- (O-D-) based travel time reliability (TTR) is fundamental to next-generation navigation tools aiming to provide both travel time and reliability information. While previous works are mostly focused on route-based TTR and use either ad
Qi Zhang, Hong Chen, Hongchao Liu, Wei Li, Yibin Zhang   +4 more
doaj   +1 more source