Results 61 to 70 of about 159,475 (252)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

A bimodal accessibility analysis of Australia’s statistical areas

Journal of Maps, 2019
The map presented in this paper summarises the combined land- and airside accessibility within Australia. To this end, we calculate a bimodal accessibility index at the scale of statistical units by aggregating the (shortest) travel time for three route ...
Sarah Meire, Ben Derudder, Kristien Ooms
doaj   +1 more source

Geographic accessibility and hospital competition for emergency blood transfusion services in Bungoma, Western Kenya

International Journal of Health Geographics, 2023
Background Estimating accessibility gaps to essential health interventions helps to allocate and prioritize health resources. Access to blood transfusion represents an important emergency health requirement.
Eda Mumo, Nathan O. Agutu, Angela K. Moturi, Anitah Cherono, Samuel K. Muchiri, Robert W. Snow, Victor A. Alegana   +6 more
doaj   +1 more source

Spectral-index asymmetries in radio galaxies: the effects of projection and light traveltime [PDF]

Monthly Notices of the Royal Astronomical Society, 1994
Since the discovery of depolarization and spectral asymmetries between the two lobes of radio galaxies and of their correlation with jet-sidedness, there has been debate concerning the origin of these effects. For the majority of sources in which asymmetries are seen, they are in the sense that the lobe that is less depolarized also has the flatter ...
Blundell, K, Alexander, P
openaire   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Impact of connected and automated vehicles on the travel time reliability of an urban network

International Journal of Transportation Science and Technology
Connected and automated vehicles (CAVs) have the potential to revolutionise the transportation industry, with a plethora of research already revealing considerable gains in safety, travel time and mobility, as well as reduced congestion and pollution. As
Shehani Samaranayake, Sai Chand, Amolika Sinha, Vinayak Dixit   +3 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Estimating uncertainty and Misery (Index) of the paratransit experience

Transportation Research Interdisciplinary Perspectives
Transportation access significantly impacts inclusion, well-being, and health. However, people with disabilities often struggle to use fixed-route transit due to mobility challenges.
Aditi Misra, Wesley Marshall, Lucy O’Sullivan, Molly Wagner, Manish Shirgaokar   +4 more
doaj   +1 more source

Data analytics approach for travel time reliability pattern analysis and prediction

Journal of Modern Transportation, 2019
Travel time reliability (TTR) is an important measure which has been widely used to represent the traffic conditions on freeways. The objective of this study is to develop a systematic approach to analyzing TTR on roadway segments along a corridor.
Zhen Chen, Wei Fan
doaj   +1 more source