Results 111 to 120 of about 15,987,795 (287)
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Decision Trees as a Tool for Real-Time Travel Time Estimation on Highways
, 2013 This paper presents a time travel estimation model based on a decision tree. Input parameter for travel time prediction is occupancy of detectors. The proposed model was tested on the most widely used arterial in Prague and also in the Czech Republic ...
Pavel Pribyl, Jakub Wosyka
core +1 more source
Applied SciencesProviding accurate information about bus travel times can help passengers plan their itinerary and reduce waiting time. However, due to various uncertainty factors and the sparsity of single-route data, traditional travel time predictions cannot ...
Zhenzhong Yin +3 more
doaj +1 more source
Spatial biology in cancer epigenetics
Molecular Oncology, EarlyView.Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley +1 more source
Commuters’ valuation of travel time variability in Barcelona [PDF]
The value given by commuters to the variability of travel times is empirically analysed using stated preference data from Barcelona (Spain). Respondents are asked to choose between alternatives that differ in terms of cost, average travel time ...
Anna Matas, Javier Asensio
core
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
ADP‐ribosylation: An emerging regulator of the epigenome
Molecular Oncology, EarlyView.ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho +2 more
wiley +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
The link between travel Time Budget and Speed: a Key relationship for urban space-time dynamics [PDF]
The relationship between travel time budget (TTB) and speed is central to transport economics and allows us to analyze travel behaviour, urban structure and the transport system.
Iragaël Joly
core
DeepST-Net: Leveraging Spatiotemporal Data Refinement for Enhanced Travel Time Prediction
Applied SciencesAccurate travel time prediction is essential for optimizing transportation systems and alleviating congestion in urban environments. This study introduces a comprehensive framework that combines advanced spatiotemporal data refinement techniques with a ...
Amira Benlecheb +3 more
doaj +1 more source