Results 141 to 150 of about 1,258,510 (324)

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

DeepST-Net: Leveraging Spatiotemporal Data Refinement for Enhanced Travel Time Prediction

Applied Sciences
Accurate travel time prediction is essential for optimizing transportation systems and alleviating congestion in urban environments. This study introduces a comprehensive framework that combines advanced spatiotemporal data refinement techniques with a ...
Amira Benlecheb, Ahmed-Chawki Chaouche, Brahim Benabderrahmane, Gregorio Díaz   +3 more
doaj   +1 more source

An integrated method for short-term prediction of road traffic conditions for intelligent transportation systems applications [PDF]

, 2013
The paper deals with the short-term prediction of road traffic conditions within Intelligent Transportation Systems applications. First, the problem of traffic modeling and the potential of different traffic monitoring technologies are discussed.
COLOMBARONI, CHIARA, FUSCO, Gaetano
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Generalization strategies for improving bus travel time prediction across networks

Journal of Urban Management
This study focuses on developing and evaluating predictive models for bus travel times adaptable to any transit network, or to new roadway segments without prior travel time data.
Zack Aemmer, Sondre Sørbø, Alfredo Clemente, Massimiliano Ruocco   +3 more
doaj   +1 more source

Data-Driven Travel Time Prediction

, 2019
Being able to accurately forecast the time of arrival of a vehicle in traffic appeals both to private drivers aiming to keep up with their schedules, and to businesses that need to organize transport logistics. THis thesis is assigned by the Swedish truck manufacturer Scania CV AB, and sets out to use GPS data from Scania's vehicle fleet to train ...
openaire   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Travel time prediction in public transportation

, 2022
ÖZET Günümüzde toplu ulaşımda, ulaşım süresinin tahmini, bilgiye kolayca erişebilen ve günlük aktivitelerini planladıkları gibi yolculuklarını da planlamak isteyen yolcular için oldukça önemlidir. Büyük şehirlerde ulaşım süresi bazı öngörülemeyen dış faktörler nedeniyle çeşitlilik göstermektedir. Bu nedenle bu çalışma, GPS cihazları ile toplanan veriyi
openaire   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source