Results 81 to 90 of about 78,588 (264)

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

A new flow chip in combination with multiphoton microscopy as a protocol for longitudinal 3D imaging of tissue calcification under shear stress

FEBS Open Bio, EarlyView.
Miniaturized flow chip platform enabling continuous perfusion and longitudinal multiphoton 3D imaging of vascular smooth muscle cell constructs under physiological flow. Brightfield imaging guides region selection, while CellTracker Green and mRuby‐labeled fetuin‐A visualize cells and mineral deposition, respectively. Magnesium supplementation markedly
Vytautas Kučikas, Aaron D. Morgan, Ignas Čiurlionis, Christian Böhm, Stefan Jockenhövel, Willi Jahnen‐Dechent, Marc A. M. J. van Zandvoort   +6 more
wiley   +1 more source

A Gini coefficient based evaluation on the reliability of travel time forecasting

Journal of King Saud University: Engineering Sciences, 2019
Traffic congestion is one of the most notorious troubles, one that undermines social costs in urbanized areas in the world. Because of the congestion problem, drivers are trying to find the shortest and most reliable paths.
Soong-Bong Lee, Seongkwan Mark Lee, Ki-Young Lee   +2 more
doaj   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

Using Minimum Travel Time to Determine Factors Influencing Travel Time Discrepancy and Variability in Tram Transit

Applied Sciences
Quality of service in urban surface transit has a great impact on sustainable urban mobility, with travel time being one of the most important indicators of service reliability.
Dino Šojat, Marko Slavulj, Matija Sikirić, Mario Ćosić   +3 more
doaj   +1 more source

Quantifying the Impact of Weather Events on Travel Time and Reliability

Journal of Advanced Transportation, 2019
It is of practical significance to understand the specific impact of weather events on the operating condition of the surface transportation system so that proactive and reactive strategies can be quickly implemented by transportation agencies to ...
Xu Zhang, Mei Chen
doaj   +1 more source

Reliability analysis on railway transport chain

International Journal of Transportation Science and Technology, 2019
This paper divides the time of railway container transport chain into the drayage time by road, the storage time at departure station, the railway transit time and the storage time at arrival station according to operation procedure.
Rong Zhang, Lu Li, Wenliang Jian
doaj   +1 more source

Intelligent Tutoring Systems for Adult Learning in STEM Disciplines

New Directions for Adult and Continuing Education, EarlyView.
ABSTRACT Intelligent tutoring systems (ITS) are reshaping adult learning in STEM by providing adaptive, data‐driven instruction across classrooms, workplaces, and informal environments. In the context of ITS, this article compares generative AI, which creates personalized explanations and practice materials, with explainable AI, which focuses on ...
Jill Zarestky, Amanda R. Lager Gleason
wiley   +1 more source

Dynamic Optimization of Exclusive Bus Lane Location Considering Reliability: A Case Study of Beijing

Applied Sciences
For metropolises like Beijing, heavy congestions cause transit passengers’ unreliable travel time, including in vehicle time and waiting time. Comparing with other managerial measures, designing a lane for bus use only is an effective method to improve ...
Weibin Kou, Shijie Zhang, Fei Liu, Lan Pang   +3 more
doaj   +1 more source