Results 71 to 80 of about 78,588 (264)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Travel Time Prediction Models and Reliability Indices for Palestine Urban Road in Baghdad City
Al-Khawarizmi Engineering Journal, 2017 Travel Time estimation and reliability measurement is an important issues for improving operation efficiency and safety of traffic roads networks.
Zainab Ahmed Al-Kaissi
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei +3 more
wiley +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source
Data analytics approach for travel time reliability pattern analysis and prediction
Journal of Modern Transportation, 2019 Travel time reliability (TTR) is an important measure which has been widely used to represent the traffic conditions on freeways. The objective of this study is to develop a systematic approach to analyzing TTR on roadway segments along a corridor.
Zhen Chen, Wei Fan
doaj +1 more source
COVID-19, Travel Time Reliability, and the Emergence of a Double-Humped Peak Period [PDF]
Findings, 2021 This paper explores the travel time variance, occupancy heterogeneity level, and average network traffic flow of Minneapolis-St. Paul freeway network and determines the time-lag relationship between travel time variance and the spatio-temporal ...
Yang Gao, David Levinson
doaj
FEBS Open Bio, EarlyView.This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill +4 more
wiley +1 more source
Connectivity Reliability on an Urban Rail Transit Network from the Perspective of Passenger Travel
Urban Rail Transit, 2019 Under the background of urbanization and the rapid development of urban rail transit (URT), serious attention has been focused on URT network reliability in recent years.
Jie Liu +3 more
doaj +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source