Results 51 to 60 of about 15,823,049 (301)

Travel Time Prediction Model of Freeway Corridor Based on Real-Time Safety Reliability

Journal of Advanced Transportation, 2020
By considering the feature of vehicle driving on the event management unit of the freeway corridor, according to the system target, a method to divide the management unit of the road network was put forward.
Huazhi Yuan, Zhaoguo Huang, Hongying Zhang   +2 more
doaj   +1 more source

Estimation of the Network Reliability for a Stochastic Cold Chain Network with Multi-State Travel Time

Applied Sciences, 2023
A stochastic cold chain (SCC) is a common supply chain in real life that emphasizes the need for commodities to arrive fresh within time constraints. In previous research on supply chains, the time factor was regarded as a fixed number.
Thi-Phuong Nguyen, Chin-Lung Huang, Yi-Kuei Lin   +2 more
doaj   +1 more source

Benefit of accident reduction considering the improvement of travel time reliability

, 2011
Traffic accidents often cause lane closure, and diminish stability of travel time as well as the level of road services. On the other hand, research on the implementation of ITS services aiming at the reduction of traffic accidents has made considerable ...
Warita, Hiroshi, Kurauchi, Fumitaka, Fumitaka Kurauchi, Tsubota, Takahiro, Kikuchi, Harumi, Harumi Kikuchi, Hiroshi Warita, Uchiumi, Kazuhito, Takahiro Tsubota, Kazuhito Uchiumi   +9 more
core   +1 more source

Prospecting the protein design landscape

FEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona, Katharina T. Stonig, Jens Meiler, Clara T. Schoeder, Monica L. Fernández‐Quintero   +4 more
wiley   +1 more source

Uncovering the Influence of Commuters’ Perception on the Reliability Ratio

Findings, 2019
The dominant method for measuring values of travel time savings (VOT) and values of travel time reliability (VOR) is discrete choice modeling. Studies using revealed preference have tended to use travel times measured by devices such as loop detectors ...
Carlos Carrion, David Levinson
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Analysis the Reliability of Travel Time in Urban Corridors in Baghdad City

Journal of Engineering
Travel-time reliability is a crucial performance measure for transportation systems. This research aims to estimate travel time and predict delay time on three routes in Baghdad city using GPS devices: Safi Al-Den Street, Palestine Street, and the Army ...
Shaymaa Hasan Taher, Zainab Ahmed Alkaissi   +1 more
doaj   +1 more source