Results 131 to 140 of about 2,266 (198)

Five-year Outcome of Aflibercept Administration with “Treat and Extend” for Neovascular Age-Related Macular Degeneration

Clinical Ophthalmology
Iori Wada,1,2 Yuji Oshima,3 Yosuke Fukuda,1 Satomi Shiose,1 Kumiko Kano,1 Keijiro Ishikawa,1 Shintaro Nakao,4 Yoshihiro Kaizu,1,5 Eiichi Hasegawa,1,2 Ram Kannan,6,7 Tatsuro Ishibashi,1 Koh-Hei Sonoda1 1Department of Ophthalmology, Graduate School of ...
Wada I, Oshima Y, Fukuda Y, Shiose S, Kano K, Ishikawa K, Nakao S, Kaizu Y, Hasegawa E, Kannan R, Ishibashi T, Sonoda KH   +11 more
doaj  

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Comparison of Monthly vs Treat-and-Extend Regimens for Individuals With Macular Edema Who Respond Well to Anti–Vascular Endothelial Growth Factor Medications [PDF]

, 2018
Ingrid U. Scott, Paul VanVeldhuisen, Michael S. Ip, Barbara A. Blodi, Neal L. Oden, Michael M. Altaweel, Daniel M. Berinstein   +6 more
openalex   +1 more source

Long-term outcomes of treat-and-extend ranibizumab with and without navigated laser for diabetic macular oedema: TREX-DME 3-year results [PDF]

, 2020
John F. Payne, Charles C. Wykoff, W. Lloyd Clark, Bonnie Bruce, David S. Boyer, David M. Brown   +5 more
openalex   +1 more source

The roles and applications of extracellular vesicles in cancer

Molecular Oncology, EarlyView.
Extracellular vesicles (EVs) are minute versions of cells limited by a lipid bilayer containing cytoplasm from the cell that releases them, but without a nucleus and thus unable to self‐reproduce. EVs contain multiple molecules (proteins, lipids, glycans, and nucleic acids) they can induce complex responses in cells.
Clotilde Théry, Daniel Louvard
wiley   +1 more source

Long‐term improvement in cardiac magnetic resonance in β‐thalassemia major patients treated with deferasirox extends to patients with abnormal baseline cardiac function [PDF]

, 2018
Maddalena Casale, Aldo Filosa, Alfonso Ragozzino, Giovanni Amendola, Domenico Roberti, Immacolata Tartaglione, Elisa De Michele, Domenico Cozzolino, Giuliana Rispoli, Palmieri Francesco, Umberto Pugliese, Saverio Scianguetta, Giuseppe Signoriello, Khaled M. Musallam, Silverio Perrotta   +14 more
openalex   +1 more source

Favourable long-term survival of patients with esophageal cancer treated with extended transhiatal esophagectomy combined with en bloc lymphadenectomy: results from a retrospective observational cohort study [PDF]

, 2020
Dino Kröll, Yves Borbély, Bastian Dislich, Tobias Haltmeier, Thomas Malinka, Matthias Biebl, Rupert Langer, Daniel Candinas, Christian Seiler   +8 more
openalex   +1 more source

Thermal proteome profiling and proteome analysis using high‐definition mass spectrometry demonstrate modulation of cholesterol biosynthesis by next‐generation galeterone analog VNPP433‐3β in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Elevated level of cholesterol is positively correlated to prostate cancer development and disease severity. Cholesterol‐lowering drugs, such as statins, are demonstrated to inhibit prostate cancer. VNPP433‐3β interrupts multiple signaling and metabolic pathways, including cholesterol biosynthesis, AR‐mediated transcription of several oncogenes, mRNA 5′
Retheesh S. Thankan, Elizabeth Thomas, Mehari M. Weldemariam, Puranik Purushottamachar, Weiliang Huang, Maureen A. Kane, Yuji Zhang, Nicholas Ambulos, Bi‐Dar Wang, David Weber, Vincent C. O. Njar   +10 more
wiley   +1 more source

The social functional outcome of being naturalistically treated with paliperidone extended-release in patients with schizophrenia

, 2015
Takashi Ohnishi, Ryoko Nakagawa, Hisanori Kobayashi, Akihide Wakamatsu, Ai Tanimura, Kazuo Morita, Toshio Yamaoka, Hideo USUI, Yoshimasa Ogawa, Akiko Fujino, Kazutake Yoshizawa   +10 more
openalex   +2 more sources

PD42-12 ONCOLOGICAL OUTCOMES OF UNFAVORABLE INTERMEDIATE-RISK IS COMPARABLE TO HIGH-RISK LOCALIZED PROSTATE CANCER IN PATIENTS TREATED WITH RADICAL PROSTATECTOMY AND EXTENDED PELVIC LYMPH NODE DISSECTION [PDF]

, 2018
Y. Ahallal, Davy Benarroche, Luis Felipe Snel Zanettini, A. Colau, Clement Charbonnier, Jean‐François Côté, Bertrand Guillonneau   +6 more
openalex   +1 more source