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Treatment-Resistant Schizophrenia
Psychiatric Clinics of North America, 2016Although treatment-resistant schizophrenia (TRS) was described 50 years ago and has a gold standard treatment with clozapine based on well-defined criteria, there is still a matter of great interest and controversy. In terms of the underlying mechanisms of the development of TRS, progress has been made for the elucidation of the neurochemical ...
Helio, Elkis, Peter F, Buckley
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Targeting Treatment-Resistant Depression
Journal of Pharmacy Practice, 2011Only 50% of depressed patients achieve remission of symptoms after 2 trials of antidepressants. Therefore one half of patients are considered treatment resistant. Studies have shown that with each failed antidepressant, chances of remission continue to decline. Untreated depressive symptoms lead to impaired social and occupational function, decline of
Monica, Mathys, Brian G, Mitchell
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Treatment-Resistant Depression
Psychotherapy and Psychosomatics, 1998Our ability to treat depression has improved with the availability of receptor-specific and chemically diverse groups of antidepressants. Even now, most of the short-term studies indicate that about 20% of depressed patients remain resistant to treatment. Therefore, it is important to properly assess the treatment-resistant depressed (TRD) patients and
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Treatment Resistant Hypertension
American Journal of Therapeutics, 2008Treatment resistant hypertension is defined as a blood pressure not achieving a goal blood pressure (
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Treatment-Resistant Schizophrenia
Psychiatric Clinics of North America, 2007This article opens with a brief history of pharmacologic treatment of schizophrenia. It then discusses the definition and treatment of treatment-resistant schizophrenia, with particular attention to clinical, biological and neuroimaging correlates, as well as the best treatment options, including the use of clozapine in patients who meet the definition
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Treatment-resistant inflammatory myopathy
Best Practice & Research Clinical Rheumatology, 2010When confronted with a dermatomyositis or polymyositis patient not responding to immunosuppressive treatment, physicians must first ask whether the original diagnosis was correct. In this review, we provide a guide to the clinical features and ancillary tests, which might be helpful in the differential diagnosis of myositis.
Herman F, Mann +2 more
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