Results 121 to 130 of about 259,075 (330)
Treatment-resistant depression: therapeutic trends, challenges, and future directions
Patient Preference and Adherence, 2012 Khalid Saad Al-HarbiMedical College, King Saud Bin Abdulaziz University for Health Sciences, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi ArabiaBackground: Patients with major depression respond to antidepressant treatment, but 10%–30%
Al-Harbi KS
doaj
Molecular Psychiatry, 2020 Treatment-resistant depression (TRD) is a major contributor to the disability caused by major depressive disorder (MDD). Primary care electronic health records provide an easily accessible approach to investigate TRD clinical and genetic characteristics.
C. Fabbri +12 more
semanticscholar +1 more source
Designing Asymmetric Memristive Behavior in Proton Mixed Conductors for Neuromorphic Applications
Advanced Functional Materials, EarlyView.Protonic devices that couple ionic and electronic transport are demonstrated as bioinspired neuromorphic elements. The devices exhibit rubber‐like asymmetric memristive behavior with slow voltage‐driven conductance increase and rapid relaxation, enabling simplified read–write operation.
Nada H. A. Besisa +6 more
wiley +1 more source
Advanced Functional Materials, EarlyView.Alumina growth narrows surface pores and seals non‐selective defects, enhancing selectivity while preserving the nanoporous graphene architecture. Additionally, the deposition enables gradient‐controlled structural modification, with intergrown alumina acting as a physical cross‐linker that stabilizes the laminar structure.
Junhyeok Kang +8 more
wiley +1 more source
Experimental pharmacological research regarding the antidepressant effect of associating doxepin and selegiline in normal mice [PDF]
, 2019 The severity and complexity of depression can vary widely among individuals, thus making single drug therapy ineffective in some cases. Taking this fact into account and using a mouse model, we set on investigating the possibility of obtaining a ...
Chiriță, Cornel +8 more
core +2 more sources
The American journal of geriatric psychiatry, 2019 BACKGROUND Elderly patients with major depression have a poorer prognosis, are less responsive to treatment, and show greater functional decline compared with younger patients, highlighting the need for effective treatment.
R. Ochs-Ross +15 more
semanticscholar +1 more source
Advanced Functional Materials, EarlyView.By mimicking the ion‐accelerating effect of ion channel receptors in neuron membranes, a biomaterials‐based ionic hydrogel (BIH) is developed, which offers a high ionic conductivity of 7.04 S m−1, outperforming conventional chitosan, cellulose, agarose, starch, and gelatin based ionic hydrogels.
Baojin Chen +7 more
wiley +1 more source
Fixed dose combination dextromethorphan-bupropion: A hope for treatment resistant depression (TRD)
Indian Journal of PsychiatryBackground: Treatment resistant depression (TRD) has been identified as non-response to depression with adequate dose and trial of two antidepressant medications of different classes. Near about 30% depressive patients are TRD cases.
Ranjan Das +3 more
doaj +1 more source
Understanding vulnerability for depression from a cognitive neuroscience perspective: a reappraisal of attentional factors and a new conceptual framework [PDF]
, 2010 We propose a framework to understand increases in vulnerability for depression after recurrent episodes that links attention processes and schema activation to negative mood states, by integrating cognitive and neurobiological findings.
De Raedt, Rudi, Koster, Ernst
core +1 more source
Advanced Functional Materials, EarlyView.We fabricated a biomimetic dendrimer‐modified thin‐film nanocomposite membrane with a coordination‐assisted ion‐selective interface. pH‐responsive polypeptide sites preferentially bind Mg2+ and promote Li+ permeation, as predicted by density functional theory calculations of metal‐ligand interactions.
Mehrasa Yassari +7 more
wiley +1 more source