Results 231 to 240 of about 21,878,726 (386)

Stochastic variation in the FOXM1 transcription program mediates replication stress tolerance

Molecular Oncology, EarlyView.
Cellular heterogeneity is a major cause of drug resistance in cancer. Segeren et al. used single‐cell transcriptomics to investigate gene expression events that correlate with sensitivity to the DNA‐damaging drugs gemcitabine and prexasertib. They show that dampened expression of transcription factor FOXM1 and its target genes protected cells against ...
Hendrika A. Segeren, Kathryn A. Wierenga, Frank M. Riemers, Elsbeth A. van Liere, Bart Westendorp   +4 more
wiley   +1 more source

The magnitude and associated factors of childhood cancer treatment abandonment at the university of Gondar comprehensive specialized hospital, Ethiopia. [PDF]

Sci Rep
Molla YM, Shad A, Wali R, Yimer MA.
europepmc   +1 more source

Targeting PRAME directly or via EZH2 inhibition overcomes retinoid resistance and represents a novel therapy for keratinocyte carcinoma

Molecular Oncology, EarlyView.
The study evaluated the function and therapeutic implications of PRAME in basal cell carcinoma (BCC) and squamous cell carcinoma (SCC). The findings demonstrate that PRAME impairs keratinocyte differentiation pathways. Furthermore, PRAME impairs anticancer response to retinoid compounds in BCC and SCC cells.
Brandon Ramchatesingh, Amelia Martinez Villarreal, Philippe Lefrançois, Jennifer Gantchev, Sriraam Sivachandran, Samy Abou Setah, Ivan V. Litvinov   +6 more
wiley   +1 more source

Physiological regulation underlying the alleviation of cadmium stress in maize seedlings by exogenous glycerol. [PDF]

Sci Rep
Li Q, Niu C, Guo J, Chen G, Li J, Sun L, Li W, Li T.   +7 more
europepmc   +1 more source

TOTAL THYROIDECTOMY IN THE TREATMENT OF PATIENTS WITH CONGESTIVE HEART FAILURE AND ANGINA PECTORIS [PDF]

, 1934
Ori Brenner, Heidi Donovan, Blaithnead Murtagh   +2 more
openalex   +1 more source

THE TREATMENT OF TETANUS [PDF]

BMJ, 1932
openaire   +5 more sources

CircCCNB1 inhibits vasculogenic mimicry by sequestering NF90 to promote miR‐15b‐5p and miR‐7‐1‐3p processing in nasopharyngeal carcinoma

Molecular Oncology, EarlyView.
CircCCNB1 expression is down‐regulated in nasopharyngeal carcinoma (NPC); thus, less NF90 protein is bound to circCCNB1 and more binds to pri‐miRNAs, blocking their (pri‐miRNAs) binding to DGCR8 and inhibiting the processing and generation of miR‐15b‐5p/miR‐7‐1‐3p. Furthermore, decreased miR‐15b‐5p/miR‐7‐1‐3p promotes the expression of the target genes
Chunmei Fan, Fenghua Tan, Jie Wu, Zhaoyang Zeng, Wenjia Guo, He Huang, Wei Xiong   +6 more
wiley   +1 more source

Clinical efficacy of azacitidine in the treatment of middle- and high-risk myelodysplastic syndrome in middle-aged and elderly patients: A retrospective study. [PDF]

Open Med (Wars)
Li L, Bian J, Su Y, Zhang C.
europepmc   +1 more source

OPERATIVE TREATMENT OF PARALYTIC GENU RECURVATUM

, 1932
Willis C. Campbell, Joseph I. Mitchell
openalex   +2 more sources

Oral Thrombin in the Treatment of Haematemesis [PDF]

, 1953
V. Edmunds
openalex   +1 more source