Results 41 to 50 of about 10,881,082 (299)
Dermatology and Therapy, 2020 Introduction Although the efficacy of monotherapy with biologics for psoriasis is well established, many patients fail to achieve complete plaque clearance from their initial biologic treatment alone.
Jerry Bagel +3 more
doaj +1 more source
FEBS Letters, EarlyView.In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley +1 more source
World Journal of Diabetes, 2014 Progression of normal glucose tolerance (NGT) to overt diabetes is mediated by a transition state called impaired glucose tolerance (IGT). Beta cell dysfunction and insulin resistance are the main defects in type 2 diabetes mellitus (type 2 DM) and even normoglycemic IGT patients manifest these defects. Beta cell dysfunction and insulin resistance also
Abdul-Ghani, Muhammad A. +2 more
openaire +4 more sources
Evaluation of the association of serum glypican-4 with prevalent and future kidney function
Scientific Reports, 2022 Serum glypican-4 (GPC4) has been identified as an insulin-sensitizing adipokine serving as a marker for body mass index and insulin resistance in humans. The association of circulating GPC4 with kidney function is to date largely unexplored.
Axel Muendlein +9 more
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FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
The treatment of hyperuricemia [PDF]
International Journal of Cardiology, 2016 Hyperuricemia has long been established as the major etiologic factor in gout. Alongside with an inflammatory state triggered by urate crystal deposition in the joints, hyperuricemia displayed additional pathophysiological consequences leading to tissue inflammation mainly in the vascular wall.
Gliozzi, Micaela +3 more
openaire +4 more sources
New surgical treatment for nonneoplastic tracheoesophageal fistula
Бюллетень сибирской медицины, 2012 Original method of nonneoplastic tracheoesophageal fistula disjunction using compression construction with shape memory has been developed. The experimental study was performed on mongrels with preliminarily made tracheoesophageal fistula.
Ye. B. Topolnitsky +1 more
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Circulating histones as clinical biomarkers in critically ill conditions
FEBS Letters, EarlyView.Circulating histones are emerging as promising biomarkers in critical illness due to their diagnostic, prognostic, and therapeutic potential. Detection methods such as ELISA and mass spectrometry provide reliable approaches for quantifying histone levels in plasma samples.
José Luis García‐Gimenez +17 more
wiley +1 more source
Evaluating IL22RA1 expression as a predictive indicator in human colon cancer progression
BMC CancerBackground Colon cancer is a prevalent malignancy of the digestive tract, consistently ranking among the top three cancers globally in both incidence and mortality.
Xuan Yin +7 more
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